biostudies-literatureJin GNCI NIH HHS95-101https://www.ebi.ac.uk/biostudies/studies/S-EPMC3556942biostudies-literatureUnknown15(1)<h4>Background</h4>Percentage of free-to-total prostate-specific antigen (%fPSA) is an independent predictor of risk for prostate cancer among men with modestly elevated level of total PSA (tPSA) in blood. Physiological and pathological factors have been shown to influence the %fPSA value and diagnostic accuracy.<h4>Materials/methods</h4>To evaluate genetic determinants of %fPSA, we conducted a genome-wide association study of serum %fPSA by genotyping 642,584 single nucleotide polymorphisms (SNPs) in 3192 men of European ancestry, each with a tPSA level of 2.5 to 10 ng/ml, that were recruited in the REduction by DUtasteride of Prostate Cancer Events study. Single nucleotide polymorphisms (SNPs) with P < 10(-5) were further evaluated among the controls of a population-based case-control stNeoplasia (New York, N.Y.)Genome-wide association study identifies loci at ATF7IP and KLK2 associated with percentage of circulating free PSA.PMC3556942P50 CA092629UC2 CA148463RC2 CA148463P50-CA92629R33 CA 127768-02R33 CA127768Zheng SLIsaacs WBLilja HKim STGronberg HXu JJin GYoung TFeng JCondreay LDTao SGao ZWiklund FRittmaster RSSun JfalseGenome-wide association study identifies loci at ATF7IP and KLK2 associated with percentage of circulating free PSA.<h4>Background</h4>Percentage of free-to-total prostate-specific antigen (%fPSA) is an independent predictor of risk for prostate cancer among men with modestly elevated level of total PSA (tPSA) in blood. Physiological and pathological factors have been shown to influence the %fPSA value and diagnostic accuracy.<h4>Materials/methods</h4>To evaluate genetic determinants of %fPSA, we conducted a genome-wide association study of serum %fPSA by genotyping 642,584 single nucleotide polymorphisms (SNPs) in 3192 men of European ancestry, each with a tPSA level of 2.5 to 10 ng/ml, that were recruited in the REduction by DUtasteride of Prostate Cancer Events study. Single nucleotide polymorphisms (SNPs) with P < 10(-5) were further evaluated among the controls of a population-based case-control st2013-01-01T00:00:00Z2013 Jan2026-05-01T07:09:59.934Z2026-04-07T16:42:16.773ZS-EPMC35569422335931910.1593/neo.121620