biostudies-literatureSrikuea RNCATS NIH HHSNIA NIH HHS519-28https://www.ebi.ac.uk/biostudies/studies/S-EPMC3558634biostudies-literatureUnknown65(2)<h4>Objective</h4>To identify muscle physiologic properties that may contribute to postexertional fatigue and malaise in women with fibromyalgia (FM).<h4>Methods</h4>Healthy postmenopausal women with (n = 11) and without (n = 11) FM, ages 51-70 years, participated in this study. Physical characteristics and responses to self-reported questionnaires were evaluated. Strength loss and tissue oxygenation in response to a fatiguing exercise protocol were used to quantify fatigability and the local muscle hemodynamic profile. Muscle biopsies were performed to assess between-group differences in baseline muscle properties using histochemical, immunohistochemical, and electron microscopic analyses.<h4>Results</h4>There was no significant difference between healthy controls and FM patients in musclArthritis and rheumatismAssociation of fibromyalgia with altered skeletal muscle characteristics which may contribute to postexertional fatigue in postmenopausal women.PMC3558634UL1 TR001998R21-AG-34279UL1 TR000117R21 AG034279UL1-TR-000117Crofford LJSymons TBLee JDPeterson CALong DEChomentowski PJSrikuea RShang YYu GfalseAssociation of fibromyalgia with altered skeletal muscle characteristics which may contribute to postexertional fatigue in postmenopausal women.<h4>Objective</h4>To identify muscle physiologic properties that may contribute to postexertional fatigue and malaise in women with fibromyalgia (FM).<h4>Methods</h4>Healthy postmenopausal women with (n = 11) and without (n = 11) FM, ages 51-70 years, participated in this study. Physical characteristics and responses to self-reported questionnaires were evaluated. Strength loss and tissue oxygenation in response to a fatiguing exercise protocol were used to quantify fatigability and the local muscle hemodynamic profile. Muscle biopsies were performed to assess between-group differences in baseline muscle properties using histochemical, immunohistochemical, and electron microscopic analyses.<h4>Results</h4>There was no significant difference between healthy controls and FM patients in muscl2013-01-01T00:00:00Z2013 Feb2025-05-29T22:29:05.112Z2019-03-27T01:04:02ZS-EPMC35586342312453510.1002/art.37763