{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Holmans P"],"funding":["Intramural NIH HHS","NIA NIH HHS","Medical Research Council","National Institute for Health Research (NIHR)","NINDS NIH HHS","Wellcome Trust","Parkinson's UK"],"pagination":["1039-49"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3561909"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(5)"],"pubmed_abstract":["Parkinson's disease (PD) is the second most common neurodegenerative disease affecting 1-2% in people >60 and 3-4% in people >80. Genome-wide association (GWA) studies have now implicated significant evidence for association in at least 18 genomic regions. We have studied a large PD-meta analysis and identified a significant excess of SNPs (P < 1 × 10(-16)) that are associated with PD but fall short of the genome-wide significance threshold. This result was independent of variants at the 18 previously implicated regions and implies the presence of additional polygenic risk alleles. To understand how these loci increase risk of PD, we applied a pathway-based analysis, testing for biological functions that were significantly enriched for genes containing variants associated with PD. Analysin"],"journal":["Human molecular genetics"],"pubmed_title":["A pathway-based analysis provides additional support for an immune-related genetic susceptibility to Parkinson's disease."],"pmcid":["PMC3561909"],"funding_grant_id":["G-0909","R01 NS041509","NF-SI-0507-10376","MC_PC_09003","Z01 AG000949","MC_G1000735","MC_G0901330","Z01 AG000950-10","G1100479","Z01 AG000950","G1100643","G0801418B","G0802462","R01 NS075321","J-0804","J-0901","K-0906","G0700943","Z01 AG000949-06"],"pubmed_authors":["Dexter DT","Trabzuni D","Williams N","Uitterlinden AG","van Hilten JJ","Lees A","Cooper JM","Moskvina V","Gasser T","Guerreiro R","Revesz T","Wood NW","Talbot K","Clarke CE","Vidailhet M","Damier P","Dillman A","Cookson MR","Huber H","Wickremaratchi M","International Parkinson's Disease Genomics Consortium","Dartigues JF","Durif F","Holmans P","Vedernikov A","Chinnery PF","Walker R","Petursson H","Burn DJ","van Dijk KD","Sadd M","Moorby C","Stockton JD","Bonin M","Corvol JC","Post B","Hu M","Buchel F","Durr A","Morris HR","Nalls MA","Chong S","Berendse HW","Potter S","Evans JR","Sidransky E","Deloukas P","Lopez G","Hofman A","Shaw K","Gibbs JR","Shoulson I","Gardner M","Simon-Sanchez J","Rivadeneira F","Pearson J","Deuschl G","Traynor BJ","Bhatia K","Scheffer H","Williams-Gray CH","Gray E","Hunt SE","Winder-Rhodes S","Hudson G","Bloem B","Wood N","Sveinbjornsdottir S","Velseboer D","Tison F","Stefansson K","Hernandez DG","Gao J","Stefansson H","Arepalli S","Barker R","Berg D","Bochdanovits Z","Foltynie T","Gustafsson O","Plagnol V","Sheerin UM","Hernandez D","Mittag F","Brice A","Pollak P","Heutink P","Edkins S","Schapira A","Chen H","Hollenbeck A","Sawcer S","Bettella F","Charlesworth G","Sharma M","Brooks J","Holton J","Martinez M","Perlmutter JS","Jones L","McNeill A","Majamaa K","Hardy J","van de Warrenburg B","Ryten M","Tashakkori-Ghanbaria A","Lesage S","Riess O","Limousin P","Illig T","Langford C","de Bie RM","Morrison KE","Biffi A","Brockmann K","Saad M","Morris H","Barrett J","Nicolaou N","Counsell C","Steinberg S","Singleton AB","Ravina B","Smith C","Bras JM","Mudanohwo E","Williams NM","Lichtner P","Rizzu P","Ben-Shlomo Y","Moore M","Harris C","Schulte C","Goate A","Huttenlocher J","Tanner CM","Lorenz D"],"additional_accession":[]},"is_claimable":false,"name":"A pathway-based analysis provides additional support for an immune-related genetic susceptibility to Parkinson's disease.","description":"Parkinson's disease (PD) is the second most common neurodegenerative disease affecting 1-2% in people >60 and 3-4% in people >80. Genome-wide association (GWA) studies have now implicated significant evidence for association in at least 18 genomic regions. We have studied a large PD-meta analysis and identified a significant excess of SNPs (P < 1 × 10(-16)) that are associated with PD but fall short of the genome-wide significance threshold. This result was independent of variants at the 18 previously implicated regions and implies the presence of additional polygenic risk alleles. To understand how these loci increase risk of PD, we applied a pathway-based analysis, testing for biological functions that were significantly enriched for genes containing variants associated with PD. Analysin","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Mar","modification":"2026-05-05T17:03:38.891Z","creation":"2026-04-07T21:52:58.868Z"},"accession":"S-EPMC3561909","cross_references":{"pubmed":["23223016"],"doi":["10.1093/hmg/dds492"]}}