biostudies-literatureUnknown10Abecasis AB<h4>Background</h4>Understanding HIV-1 subtype distribution and epidemiology can assist preventive measures and clinical decisions. Sequence variation may affect antiviral drug resistance development, disease progression, evolutionary rates and transmission routes.<h4>Results</h4>We investigated the subtype distribution of HIV-1 in Europe and Israel in a representative sample of patients diagnosed between 2002 and 2005 and related it to the demographic data available. 2793 PRO-RT sequences were subtyped either with the REGA Subtyping tool or by a manual procedure that included phylogenetic tree and recombination analysis. The most prevalent subtypes/CRFs in our dataset were subtype B (66.1%), followed by sub-subtype A1 (6.9%), subtype C (6.8%) and CRF02_AG (4.7%). Substantial differences iRetrovirology7https://www.ebi.ac.uk/biostudies/studies/S-EPMC3564855biostudies-literatureHIV-1 subtype distribution and its demographic determinants in newly diagnosed patients in Europe suggest highly compartmentalized epidemics.PMC3564855Van de Vijver DAParedes RKolupajeva TAsjo BBeshkov DBoucher CAWensing AMVercauteren JVandamme AMKucherer CTheys KLiitsola KAbecasis ABCamacho RJGrossman ZHamouda OHorban AKorn KOtelea DNielsen CGriskevicius APuchhammer-Stockl EStruck DSonnerborg AParaskevis DSchmit JCStanekova DLinka MClotet BPoljak MStanojevic MAlbert JBalotta CDe Gascun CKostrikis LGfalseHIV-1 subtype distribution and its demographic determinants in newly diagnosed patients in Europe suggest highly compartmentalized epidemics.<h4>Background</h4>Understanding HIV-1 subtype distribution and epidemiology can assist preventive measures and clinical decisions. Sequence variation may affect antiviral drug resistance development, disease progression, evolutionary rates and transmission routes.<h4>Results</h4>We investigated the subtype distribution of HIV-1 in Europe and Israel in a representative sample of patients diagnosed between 2002 and 2005 and related it to the demographic data available. 2793 PRO-RT sequences were subtyped either with the REGA Subtyping tool or by a manual procedure that included phylogenetic tree and recombination analysis. The most prevalent subtypes/CRFs in our dataset were subtype B (66.1%), followed by sub-subtype A1 (6.9%), subtype C (6.8%) and CRF02_AG (4.7%). Substantial differences i2013-01-01T00:00:00Z2013 Jan2026-05-05T09:32:13.749Z2026-04-07T21:38:42.632ZS-EPMC35648552331709310.1186/1742-4690-10-7