{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Fisher G"],"funding":["Cancer Research UK","NCI NIH HHS"],"pagination":["271-7"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3566811"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["108(2)"],"pubmed_abstract":["<h4>Background</h4>Standard clinical parameters cannot accurately differentiate indolent from aggressive prostate cancer. Our previous work showed that immunohistochemical (IHC) Ki-67 improved prediction of prostate cancer death in a cohort of conservatively treated clinically localised prostate cancers diagnosed by transurethral resection of the prostate (TURP). Here, we present results in a more clinically relevant needle biopsy cohort.<h4>Methods</h4>Biopsy specimens were microarrayed. The percentage of Ki-67 positively stained malignant cells per core was measured and the maximum score per individual used in analysis of time to death from prostate cancer using a Cox proportional hazards model.<h4>Results</h4>In univariate analysis (n=293), the hazard ratio (HR) (95% confidence interval"],"journal":["British journal of cancer"],"pubmed_title":["Prognostic value of Ki-67 for prostate cancer death in a conservatively managed cohort."],"pmcid":["PMC3566811"],"funding_grant_id":["P30 CA008748"],"pubmed_authors":["Kudahetti S","Transatlantic Prostate Group","Yang ZH","Scardino P","Fisher G","Berney DM","Moller H","Cuzick J"],"additional_accession":[]},"is_claimable":false,"name":"Prognostic value of Ki-67 for prostate cancer death in a conservatively managed cohort.","description":"<h4>Background</h4>Standard clinical parameters cannot accurately differentiate indolent from aggressive prostate cancer. Our previous work showed that immunohistochemical (IHC) Ki-67 improved prediction of prostate cancer death in a cohort of conservatively treated clinically localised prostate cancers diagnosed by transurethral resection of the prostate (TURP). Here, we present results in a more clinically relevant needle biopsy cohort.<h4>Methods</h4>Biopsy specimens were microarrayed. The percentage of Ki-67 positively stained malignant cells per core was measured and the maximum score per individual used in analysis of time to death from prostate cancer using a Cox proportional hazards model.<h4>Results</h4>In univariate analysis (n=293), the hazard ratio (HR) (95% confidence interval","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Feb","modification":"2025-04-04T10:11:59.281Z","creation":"2019-03-27T01:04:29Z"},"accession":"S-EPMC3566811","cross_references":{"pubmed":["23329234"],"doi":["10.1038/bjc.2012.598"]}}