biostudies-literatureFisher GCancer Research UKNCI NIH HHS271-7https://www.ebi.ac.uk/biostudies/studies/S-EPMC3566811biostudies-literatureUnknown108(2)<h4>Background</h4>Standard clinical parameters cannot accurately differentiate indolent from aggressive prostate cancer. Our previous work showed that immunohistochemical (IHC) Ki-67 improved prediction of prostate cancer death in a cohort of conservatively treated clinically localised prostate cancers diagnosed by transurethral resection of the prostate (TURP). Here, we present results in a more clinically relevant needle biopsy cohort.<h4>Methods</h4>Biopsy specimens were microarrayed. The percentage of Ki-67 positively stained malignant cells per core was measured and the maximum score per individual used in analysis of time to death from prostate cancer using a Cox proportional hazards model.<h4>Results</h4>In univariate analysis (n=293), the hazard ratio (HR) (95% confidence intervalBritish journal of cancerPrognostic value of Ki-67 for prostate cancer death in a conservatively managed cohort.PMC3566811P30 CA008748Kudahetti STransatlantic Prostate GroupYang ZHScardino PFisher GBerney DMMoller HCuzick JfalsePrognostic value of Ki-67 for prostate cancer death in a conservatively managed cohort.<h4>Background</h4>Standard clinical parameters cannot accurately differentiate indolent from aggressive prostate cancer. Our previous work showed that immunohistochemical (IHC) Ki-67 improved prediction of prostate cancer death in a cohort of conservatively treated clinically localised prostate cancers diagnosed by transurethral resection of the prostate (TURP). Here, we present results in a more clinically relevant needle biopsy cohort.<h4>Methods</h4>Biopsy specimens were microarrayed. The percentage of Ki-67 positively stained malignant cells per core was measured and the maximum score per individual used in analysis of time to death from prostate cancer using a Cox proportional hazards model.<h4>Results</h4>In univariate analysis (n=293), the hazard ratio (HR) (95% confidence interval2013-01-01T00:00:00Z2013 Feb2025-04-04T10:11:59.281Z2019-03-27T01:04:29ZS-EPMC35668112332923410.1038/bjc.2012.598