biostudies-literatureUnknown108(2)Mayer A<h4>Background</h4>Experimental studies have established a causal connection between tumour hypoxia, hypoxia-associated proteome changes and downregulation of E-cadherin, the final common pathway of epithelial-to-mesenchymal transition (EMT). Our study aimed at elucidating the interrelationship of these processes in cancers of the uterine cervix in vivo.<h4>Methods</h4>Tumour oxygenation was assessed in 48 squamous cell carcinomas (SCC) of the uterine cervix using polarographic needle electrodes. The expression pattern of E-cadherin was investigated by immunohistochemistry and western blotting, and was compared with that of the hypoxia-inducible proteins glucose transporter (GLUT)-1 and carbonic anhydrase (CA) IX in biopsy specimens of the oxygenation measurement tracks.<h4>Results</h4>TheBritish journal of cancer402-8https://www.ebi.ac.uk/biostudies/studies/S-EPMC3566820biostudies-literatureLacking hypoxia-mediated downregulation of E-cadherin in cancers of the uterine cervix.PMC3566820Schlischewsky NHorn LCHockel MSchmidberger HMayer AVaupel PfalseLacking hypoxia-mediated downregulation of E-cadherin in cancers of the uterine cervix.<h4>Background</h4>Experimental studies have established a causal connection between tumour hypoxia, hypoxia-associated proteome changes and downregulation of E-cadherin, the final common pathway of epithelial-to-mesenchymal transition (EMT). Our study aimed at elucidating the interrelationship of these processes in cancers of the uterine cervix in vivo.<h4>Methods</h4>Tumour oxygenation was assessed in 48 squamous cell carcinomas (SCC) of the uterine cervix using polarographic needle electrodes. The expression pattern of E-cadherin was investigated by immunohistochemistry and western blotting, and was compared with that of the hypoxia-inducible proteins glucose transporter (GLUT)-1 and carbonic anhydrase (CA) IX in biopsy specimens of the oxygenation measurement tracks.<h4>Results</h4>The2013-01-01T00:00:00Z2013 Feb2025-04-21T21:41:17.445Z2019-03-27T01:04:29ZS-EPMC35668202332220910.1038/bjc.2012.570