biostudies-literaturePorcu EIntramural NIH HHSNCATS NIH HHSNIA NIH HHSNCRR NIH HHSNHLBI NIH HHSCIHRNIDDK NIH HHSMedical Research CouncilDutch Research Council (NWO)NIMHD NIH HHSNational Institute for Health Research (NIHR)Chief Scientist OfficeWellcome TrustBiotechnology and Biological Sciences Research Councile1003266https://www.ebi.ac.uk/biostudies/studies/S-EPMC3567175biostudies-literatureUnknown9(2)Thyroid hormone is essential for normal metabolism and development, and overt abnormalities in thyroid function lead to common endocrine disorders affecting approximately 10% of individuals over their life span. In addition, even mild alterations in thyroid function are associated with weight changes, atrial fibrillation, osteoporosis, and psychiatric disorders. To identify novel variants underlying thyroid function, we performed a large meta-analysis of genome-wide association studies for serum levels of the highly heritable thyroid function markers TSH and FT4, in up to 26,420 and 17,520 euthyroid subjects, respectively. Here we report 26 independent associations, including several novel loci for TSH (PDE10A, VEGFA, IGFBP5, NFIA, SOX9, PRDM11, FGF7, INSR, ABO, MIR1179, NRG1, MBIP, ITPK1,PLoS geneticsA meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function.PMC3567175N01 HC085086N01-HC-25195R56 AG023629WT098051HL087652WT091310,085541/Z/08/ZM01 RR 16500R01 AG023629WT089062M01 RR016500N01 HC075150G0700704263 MD 9164R01 AG015928BB/F019394/1UL1 TR000124AG-15928MR/K026992/1R01 AG18728N01 HC055222N01 HC-55222R01 MD009164P30 DK063491DK063491R01 AG027058M01 RR000052NF-SI-0611-10219N01-HC-85239N01-HC-75150AG-20098175.010.200R56 AG020098N01-HC-85079N01-AG-1-2109M01 RR 000052U01 HL080295AG-027058ETM/55N01 HC025195N01-HC-85080U01 HL72515085541/Z/08/ZU01 HL072515WT091310HHSN268201200036CN02-HL-6-4278N01 HC035129263 MD 821336N01-HC-85085N01-HC-85086N01-HC-85083N01-HC-85084N01-HC-35129N01-HC-85081R01 AG020098R01 HL087652N01-HC-85082UL1TR000124N01 HC015103N01 HC-15103HL080295911-03-012HL105756R01 HL080295N01-HC-45133R01 AG018728N01 HC085079R01 HL105756AG-023629N01 HC045133Ford IGogele MToniolo DPsaty BMRotter JIUitterlinden AGJukema JWUsala GSanna SMasciullo CPalotie AStott DJPiras MGRichards JBDeary IJPistis GWilson SGSabra MMFerrucci LSpector TDVaidya BHermus ARPorcu EFrayling TMBrown SJLahti JO'Connell JRCucca FKiemeney LANolte IMShuldiner ARLopez LMJensen RAEriksson JGNagaraja RBuckley BMSweep FCBohringer SNetea-Maier RTPersani LHattersley ATFreathy RMDavies GDeelen JKajantie EWestendorp RGWolffenbuttel BHSlagboom EPMariotti SCappola ARFox CSVisser WEBeekman MFugazzola LSattar NPeeters RPBandinelli SSchlessinger DTanaka Tde Craen AJHofman APramstaller PPKloppenburg MWiden Eden Heijer MArnold AHouwing-Duistermaat JJvan der Klauw MMSoranzo NCamaschella Cde Visser MCMinelli CVermeulen SHZhai Gvan Mullem ARaikkonen KVolpato CBRivadeneira FSala CShields BMVisser TJLim EMForsen TMeulenbelt IStarr JMvan Heemst DNaitza SMedici MBos SDLiu CWalsh JPHicks AATrompet SMitchell BDfalseA meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function.Thyroid hormone is essential for normal metabolism and development, and overt abnormalities in thyroid function lead to common endocrine disorders affecting approximately 10% of individuals over their life span. In addition, even mild alterations in thyroid function are associated with weight changes, atrial fibrillation, osteoporosis, and psychiatric disorders. To identify novel variants underlying thyroid function, we performed a large meta-analysis of genome-wide association studies for serum levels of the highly heritable thyroid function markers TSH and FT4, in up to 26,420 and 17,520 euthyroid subjects, respectively. Here we report 26 independent associations, including several novel loci for TSH (PDE10A, VEGFA, IGFBP5, NFIA, SOX9, PRDM11, FGF7, INSR, ABO, MIR1179, NRG1, MBIP, ITPK1,2013-01-01T00:00:00Z20132026-05-05T11:12:22.994Z2026-04-07T21:38:37.785ZS-EPMC35671752340890610.1371/journal.pgen.1003266