{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(2)"],"submitter":["Kurashima K"],"pubmed_abstract":["Mitochondria are highly dynamic organelles that continuously fuse and divide. To maintain mitochondria, cells establish an equilibrium of fusion and fission events, which are mediated by dynamin-like GTPases. We previously showed that an mus-10 strain, a mutagen-sensitive strain of the filamentous fungus Neurospora crassa, is defective in an F-box protein that is essential for the maintenance of mitochondrial DNA (mtDNA), long life span, and mitochondrial morphology. Similarly, a uvs-5 mutant accumulates deletions within its mtDNA, has a shortened life span, and harbors fragmented mitochondria, the latter of which is indicative of an imbalance between mitochondrial fission and fusion. Since the uvs-5 mutation maps very close to the locus of fzo1, encoding a mitofusin homologue thought to m"],"journal":["Eukaryotic cell"],"pagination":["233-43"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3571291"],"repository":["biostudies-literature"],"pubmed_title":["A uvs-5 strain is deficient for a mitofusin gene homologue, fzo1, involved in maintenance of long life span in Neurospora crassa."],"pmcid":["PMC3571291"],"pubmed_authors":["Kurashima K","Tanaka S","Hatakeyama S","Inoue H","Chae M"],"additional_accession":[]},"is_claimable":false,"name":"A uvs-5 strain is deficient for a mitofusin gene homologue, fzo1, involved in maintenance of long life span in Neurospora crassa.","description":"Mitochondria are highly dynamic organelles that continuously fuse and divide. To maintain mitochondria, cells establish an equilibrium of fusion and fission events, which are mediated by dynamin-like GTPases. We previously showed that an mus-10 strain, a mutagen-sensitive strain of the filamentous fungus Neurospora crassa, is defective in an F-box protein that is essential for the maintenance of mitochondrial DNA (mtDNA), long life span, and mitochondrial morphology. Similarly, a uvs-5 mutant accumulates deletions within its mtDNA, has a shortened life span, and harbors fragmented mitochondria, the latter of which is indicative of an imbalance between mitochondrial fission and fusion. Since the uvs-5 mutation maps very close to the locus of fzo1, encoding a mitofusin homologue thought to m","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Feb","modification":"2026-05-04T16:04:13.383Z","creation":"2026-04-07T20:42:13.26Z"},"accession":"S-EPMC3571291","cross_references":{"pubmed":["23223037"],"doi":["10.1128/ec.00226-12","10.1128/EC.00226-12"]}}