{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mutter RW"],"funding":["NCI NIH HHS"],"pagination":["1783-90"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3580772"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["82(5)"],"pubmed_abstract":["Chest wall (CW) pain has recently been recognized as an important adverse effect of stereotactic body radiation therapy (SBRT) for non-small-cell lung cancer (NSCLC). We developed a dose-volume model to predict the development of this toxicity.A total of 126 patients with primary, clinically node-negative NSCLC received three to five fractions of SBRT to doses of 40-60 Gy and were prospectively followed. The dose-absolute volume histograms of two different definitions of the CW as an organ at risk (CW3cm and CW2cm) were examined for all 126 patients.With a median follow-up of 16 months, the 2-year estimated actuarial incidence of Grade ? 2 CW pain was 39%. The median time to onset of Grade ? 2 CW pain (National Cancer Institute Common Terminology Criteria for Adverse Events, Version 3.0) was 9 months. There was no predictive advantage for biologically corrected dose over physical dose. Neither fraction number (p = 0.07) nor prescription dose (p = 0.07) were significantly correlated with the development of Grade ? 2 CW pain. Cox Proportional Hazards analysis identified significant correlation with a broad range of dose-volume combinations, with the CW volume receiving 30 Gy (V30) as one of the strongest predictors (p < 0.001). CW2cm consistently enabled better prediction of CW toxicity. When a physical dose of 30 Gy was received by more than 70 cm(3) of CW2cm, there was a significant correlation with Grade ? 2 CW pain (p = 0.004).CW toxicity after SBRT is common and long-term follow-up is needed to identify affected patients. A volume of CW ? 70 cm(3) receiving 30 Gy is significantly correlated with Grade ? 2 CW pain. We are currently applying this constraint at our institution for patients receiving thoracic SBRT. An actuarial atlas of our data is provided as an electronic supplement to facilitate data-sharing and meta-analysis relating to CW pain."],"journal":["International journal of radiation oncology, biology, physics"],"pubmed_title":["Dose-volume parameters predict for the development of chest wall pain after stereotactic body radiation for lung cancer."],"pmcid":["PMC3580772"],"funding_grant_id":["1R01CA129182-01A2","R01 CA129182"],"pubmed_authors":["Rosenzweig KE","Abreu A","Yorke E","Jackson A","Mutter RW","Liu F"],"additional_accession":[]},"is_claimable":false,"name":"Dose-volume parameters predict for the development of chest wall pain after stereotactic body radiation for lung cancer.","description":"Chest wall (CW) pain has recently been recognized as an important adverse effect of stereotactic body radiation therapy (SBRT) for non-small-cell lung cancer (NSCLC). We developed a dose-volume model to predict the development of this toxicity.A total of 126 patients with primary, clinically node-negative NSCLC received three to five fractions of SBRT to doses of 40-60 Gy and were prospectively followed. The dose-absolute volume histograms of two different definitions of the CW as an organ at risk (CW3cm and CW2cm) were examined for all 126 patients.With a median follow-up of 16 months, the 2-year estimated actuarial incidence of Grade ? 2 CW pain was 39%. The median time to onset of Grade ? 2 CW pain (National Cancer Institute Common Terminology Criteria for Adverse Events, Version 3.0) was 9 months. There was no predictive advantage for biologically corrected dose over physical dose. Neither fraction number (p = 0.07) nor prescription dose (p = 0.07) were significantly correlated with the development of Grade ? 2 CW pain. Cox Proportional Hazards analysis identified significant correlation with a broad range of dose-volume combinations, with the CW volume receiving 30 Gy (V30) as one of the strongest predictors (p < 0.001). CW2cm consistently enabled better prediction of CW toxicity. When a physical dose of 30 Gy was received by more than 70 cm(3) of CW2cm, there was a significant correlation with Grade ? 2 CW pain (p = 0.004).CW toxicity after SBRT is common and long-term follow-up is needed to identify affected patients. A volume of CW ? 70 cm(3) receiving 30 Gy is significantly correlated with Grade ? 2 CW pain. We are currently applying this constraint at our institution for patients receiving thoracic SBRT. An actuarial atlas of our data is provided as an electronic supplement to facilitate data-sharing and meta-analysis relating to CW pain.","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Apr","modification":"2020-10-29T13:12:23Z","creation":"2019-03-27T01:05:12Z"},"accession":"S-EPMC3580772","cross_references":{"pubmed":["21868173"],"doi":["10.1016/j.ijrobp.2011.03.053"]}}