{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Williams FM"],"funding":["Intramural NIH HHS","NIA NIH HHS","NCRR NIH HHS","NIDDK NIH HHS","NHLBI NIH HHS","NHGRI NIH HHS","National Institute for Health Research (NIHR)","NINDS NIH HHS","Vivensa Foundation","Wellcome Trust","PHS HHS"],"pagination":["16-31"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3582024"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["73(1)"],"pubmed_abstract":["<h4>Objective</h4>End-stage coagulation and the structure/function of fibrin are implicated in the pathogenesis of ischemic stroke. We explored whether genetic variants associated with end-stage coagulation in healthy volunteers account for the genetic predisposition to ischemic stroke and examined their influence on stroke subtype.<h4>Methods</h4>Common genetic variants identified through genome-wide association studies of coagulation factors and fibrin structure/function in healthy twins (n = 2,100, Stage 1) were examined in ischemic stroke (n = 4,200 cases) using 2 independent samples of European ancestry (Stage 2). A third clinical collection having stroke subtyping (total 8,900 cases, 55,000 controls) was used for replication (Stage 3).<h4>Results</h4>Stage 1 identified 524 single nuc"],"journal":["Annals of neurology"],"pubmed_title":["Ischemic stroke is associated with the ABO locus: the EuroCLOT study."],"pmcid":["PMC3582024"],"funding_grant_id":["U01 NS069208","P30DK072488","U01NS069208","095626","HL087652","R01 HL075366","WT098051","R01 AG016495","HHSN268201100009I","R01 AG023629","P30 DK072488","UL1 RR025005","HHSN268201100009C","HL093029","U01 HG004436","R01 NS039987","OSRP2/1006","N01 HC055222","R01 NS-39987","Z01 AG000954","N01 HC-55222","R01 NS045012","P30 DK063491","098051","R01 NS45012","N01-HC-85239","AG-20098","N01-HC-75150","U01 HG004402","N01-HC-85079","U01 HL080295","UL1 RR033176","N01 HC025195","N01-HC-85080","HHSN268200782096C","WT091310","N02-HL-6-4278","N01 HC035129","R01 NS-42733","N01-HC-85086","N01-HC-85083","P30 AG010129","U01 HG 004446","N01-HC-85081","R01 AG008122","R01 AG020098","R01 HL087652","R01HL086694","N01-HC-85082","R01 HL073410","HHSN268200625226C","HL080295","R01 NS017950","HL105756","R01 HL080295","090532/Z09/Z","075491","R01 HL105756","AG-023629","R01 HL087641","N01 HC085084","N01 HC085083","N01 HC085082","N01 HC085081","N01 HC085086","N01 HC085085","N01-HC-25195","N01 HC085080","R01 AG031287","R56 AG023629","090532","R01 HL059367","HHSN268201100005C","N01 HC075150","AG08122","R01 NS042733","R01 HL085251","NS17950","HHSN268201100005I","R01HL087641","HHSN268201100005G","R01 AG015928","U01 NS069208-01","R01 HL093029","N02 HL064278","HHSN268201100006C","R01HL59367","DK063491","085475/Z/08/Z","Z01 AG-000015-50","HHSN268201100010C","UL 1RR033176","R01 HL086694","R01 AG027058","U01 HG004446","HHSN268201100011I","R56 AG020098","AG-027058","AG16495","HHSN268201100007C","HHSN268201100011C","AG031287","085475/B/08/Z","HL075366","HHSN268201100007I","N01 HC015103","WT084724MA","UL1RR025005","Z01 AG000015","HHSN268201100008C","R01 AG033193","U01HG004402","AG033193","Z01 AG-000954-06","N01 HC085079","075491/Z/04","HHSN268201100008I","N01 HC045133","HHSN268201100012C"],"pubmed_authors":["Ricketts M","Vukcevic D","Duncanson A","Sawcer SJ","Plomin R","Palotie A","Wood NW","Meschia J","Mathew CG","Wellcome Trust Case Control Consortium 2","Band G","Ikram MA","Su Z","Widaa S","Holliday EG","Trembath RC","Blackwell JM","Surdulescu G","MetaStroke","Potter SC","Furie KL","Corvin A","Hodgkiss D","Scott RJ","Palmer CN","Gretarsdottir S","Thorsteinsdottir U","DeStefano A","Carter AM","Salomaa V","Whittaker P","Deloukas P","Donnelly P","Hofman A","Levi C","Viswanathan AC","Pirinen M","Boncoraglio GB","Cheng YC","Grant PJ","Longstreth W","Liddle J","Kaunisto M","Brown MA","Bis JC","Bevan S","Giannoulatou E","Parati EA","Hunt SE","Gray E","Pearson R","Ferrario M","Mitchell BD","MOnica Risk, Genetics, Archiving and Monograph","Saarela O","Thorleifsson G","Stefansson K","Clarke R","International Stroke Genetics Consortium","Amouyel P","Sudlow C","Ferrieres J","Rautanen A","Hammond N","Spector TD","Bellenguez C","McCann OT","Spencer CC","Evans A","Barroso I","Virtamo J","Sharma P","Gwilliam R","Edkins S","Markus HS","Freeman C","Dichgans M","Casas JP","Waller M","Wagner P","Bramon E","Traylor M","Weston P","Farrall M","Gillman M","Psaty B","Attia J","Fornage M","Nalls M","Gschwendtner A","Rothwell PM","Blackburn H","Bumpstead SJ","Ravindrarajah R","Hysi PG","EuroCLOT Investigators","Langford C","Jankowski J","Soranzo N","Hellenthal G","Dronov S","Williams FM","Helgadottir A","Seshadri S","Rosand J","Mosely TH","Wiklund PG","Arveiler D","Silander K","Kuulasmaa K","Strange A","Jayakumar A"],"additional_accession":[]},"is_claimable":false,"name":"Ischemic stroke is associated with the ABO locus: the EuroCLOT study.","description":"<h4>Objective</h4>End-stage coagulation and the structure/function of fibrin are implicated in the pathogenesis of ischemic stroke. We explored whether genetic variants associated with end-stage coagulation in healthy volunteers account for the genetic predisposition to ischemic stroke and examined their influence on stroke subtype.<h4>Methods</h4>Common genetic variants identified through genome-wide association studies of coagulation factors and fibrin structure/function in healthy twins (n = 2,100, Stage 1) were examined in ischemic stroke (n = 4,200 cases) using 2 independent samples of European ancestry (Stage 2). A third clinical collection having stroke subtyping (total 8,900 cases, 55,000 controls) was used for replication (Stage 3).<h4>Results</h4>Stage 1 identified 524 single nuc","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Jan","modification":"2026-04-29T21:47:36.434Z","creation":"2026-04-07T15:32:27.232Z"},"accession":"S-EPMC3582024","cross_references":{"pubmed":["23381943"],"doi":["10.1002/ana.23838"]}}