biostudies-literatureWilliams FMIntramural NIH HHSNIA NIH HHSNCRR NIH HHSNIDDK NIH HHSNHLBI NIH HHSNHGRI NIH HHSNational Institute for Health Research (NIHR)NINDS NIH HHSVivensa FoundationWellcome TrustPHS HHS16-31https://www.ebi.ac.uk/biostudies/studies/S-EPMC3582024biostudies-literatureUnknown73(1)<h4>Objective</h4>End-stage coagulation and the structure/function of fibrin are implicated in the pathogenesis of ischemic stroke. We explored whether genetic variants associated with end-stage coagulation in healthy volunteers account for the genetic predisposition to ischemic stroke and examined their influence on stroke subtype.<h4>Methods</h4>Common genetic variants identified through genome-wide association studies of coagulation factors and fibrin structure/function in healthy twins (n = 2,100, Stage 1) were examined in ischemic stroke (n = 4,200 cases) using 2 independent samples of European ancestry (Stage 2). A third clinical collection having stroke subtyping (total 8,900 cases, 55,000 controls) was used for replication (Stage 3).<h4>Results</h4>Stage 1 identified 524 single nucAnnals of neurologyIschemic stroke is associated with the ABO locus: the EuroCLOT study.PMC3582024U01 NS069208P30DK072488U01NS069208095626HL087652R01 HL075366WT098051R01 AG016495HHSN268201100009IR01 AG023629P30 DK072488UL1 RR025005HHSN268201100009CHL093029U01 HG004436R01 NS039987OSRP2/1006N01 HC055222R01 NS-39987Z01 AG000954N01 HC-55222R01 NS045012P30 DK063491098051R01 NS45012N01-HC-85239AG-20098N01-HC-75150U01 HG004402N01-HC-85079U01 HL080295UL1 RR033176N01 HC025195N01-HC-85080HHSN268200782096CWT091310N02-HL-6-4278N01 HC035129R01 NS-42733N01-HC-85086N01-HC-85083P30 AG010129U01 HG 004446N01-HC-85081R01 AG008122R01 AG020098R01 HL087652R01HL086694N01-HC-85082R01 HL073410HHSN268200625226CHL080295R01 NS017950HL105756R01 HL080295090532/Z09/Z075491R01 HL105756AG-023629R01 HL087641N01 HC085084N01 HC085083N01 HC085082N01 HC085081N01 HC085086N01 HC085085N01-HC-25195N01 HC085080R01 AG031287R56 AG023629090532R01 HL059367HHSN268201100005CN01 HC075150AG08122R01 NS042733R01 HL085251NS17950HHSN268201100005IR01HL087641HHSN268201100005GR01 AG015928U01 NS069208-01R01 HL093029N02 HL064278HHSN268201100006CR01HL59367DK063491085475/Z/08/ZZ01 AG-000015-50HHSN268201100010CUL 1RR033176R01 HL086694R01 AG027058U01 HG004446HHSN268201100011IR56 AG020098AG-027058AG16495HHSN268201100007CHHSN268201100011CAG031287085475/B/08/ZHL075366HHSN268201100007IN01 HC015103WT084724MAUL1RR025005Z01 AG000015HHSN268201100008CR01 AG033193U01HG004402AG033193Z01 AG-000954-06N01 HC085079075491/Z/04HHSN268201100008IN01 HC045133HHSN268201100012CRicketts MVukcevic DDuncanson ASawcer SJPlomin RPalotie AWood NWMeschia JMathew CGWellcome Trust Case Control Consortium 2Band GIkram MASu ZWidaa SHolliday EGTrembath RCBlackwell JMSurdulescu GMetaStrokePotter SCFurie KLCorvin AHodgkiss DScott RJPalmer CNGretarsdottir SThorsteinsdottir UDeStefano ACarter AMSalomaa VWhittaker PDeloukas PDonnelly PHofman ALevi CViswanathan ACPirinen MBoncoraglio GBCheng YCGrant PJLongstreth WLiddle JKaunisto MBrown MABis JCBevan SGiannoulatou EParati EAHunt SEGray EPearson RFerrario MMitchell BDMOnica Risk, Genetics, Archiving and MonographSaarela OThorleifsson GStefansson KClarke RInternational Stroke Genetics ConsortiumAmouyel PSudlow CFerrieres JRautanen AHammond NSpector TDBellenguez CMcCann OTSpencer CCEvans ABarroso IVirtamo JSharma PGwilliam REdkins SMarkus HSFreeman CDichgans MCasas JPWaller MWagner PBramon ETraylor MWeston PFarrall MGillman MPsaty BAttia JFornage MNalls MGschwendtner ARothwell PMBlackburn HBumpstead SJRavindrarajah RHysi PGEuroCLOT InvestigatorsLangford CJankowski JSoranzo NHellenthal GDronov SWilliams FMHelgadottir ASeshadri SRosand JMosely THWiklund PGArveiler DSilander KKuulasmaa KStrange AJayakumar AfalseIschemic stroke is associated with the ABO locus: the EuroCLOT study.<h4>Objective</h4>End-stage coagulation and the structure/function of fibrin are implicated in the pathogenesis of ischemic stroke. We explored whether genetic variants associated with end-stage coagulation in healthy volunteers account for the genetic predisposition to ischemic stroke and examined their influence on stroke subtype.<h4>Methods</h4>Common genetic variants identified through genome-wide association studies of coagulation factors and fibrin structure/function in healthy twins (n = 2,100, Stage 1) were examined in ischemic stroke (n = 4,200 cases) using 2 independent samples of European ancestry (Stage 2). A third clinical collection having stroke subtyping (total 8,900 cases, 55,000 controls) was used for replication (Stage 3).<h4>Results</h4>Stage 1 identified 524 single nuc2013-01-01T00:00:00Z2013 Jan2026-04-29T21:47:36.434Z2026-04-07T15:32:27.232ZS-EPMC35820242338194310.1002/ana.23838