{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["He R"],"funding":["NCI NIH HHS"],"pagination":["2064-6"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3586706"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["49(20)"],"pubmed_abstract":["Mycobacterium protein tyrosine phosphatase B (mPTPB) is essential for the survival and persistence of Mycobacterium in the host. Thus small molecule inhibitors of mPTPB are potential anti-TB agents. We developed an efficient organocatalytic multicomponent reaction (MCR) between pyrrole, formaldehyde and aniline, affording a potent and selective mPTPB inhibitor with an IC(50) value of 1.5 μM and >50-fold specificity. Our studies provide a successful example of using organocatalysis as a discovery tool for the acquisition of PTP inhibitors."],"journal":["Chemical communications (Cambridge, England)"],"pubmed_title":["Organocatalytic multicomponent reaction for the acquisition of a selective inhibitor of mPTPB, a virulence factor of tuberculosis."],"pmcid":["PMC3586706"],"funding_grant_id":["R01 CA152194","CA152194"],"pubmed_authors":["Zeng LF","Wu L","He Y","Gunawan AM","Zhang ZY","He R"],"additional_accession":[]},"is_claimable":false,"name":"Organocatalytic multicomponent reaction for the acquisition of a selective inhibitor of mPTPB, a virulence factor of tuberculosis.","description":"Mycobacterium protein tyrosine phosphatase B (mPTPB) is essential for the survival and persistence of Mycobacterium in the host. Thus small molecule inhibitors of mPTPB are potential anti-TB agents. We developed an efficient organocatalytic multicomponent reaction (MCR) between pyrrole, formaldehyde and aniline, affording a potent and selective mPTPB inhibitor with an IC(50) value of 1.5 μM and >50-fold specificity. Our studies provide a successful example of using organocatalysis as a discovery tool for the acquisition of PTP inhibitors.","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Mar","modification":"2025-04-04T14:19:19.942Z","creation":"2019-03-27T01:05:30Z"},"accession":"S-EPMC3586706","cross_references":{"pubmed":["23380872"],"doi":["10.1039/c3cc38961h"]}}