{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ardehali R"],"funding":["Howard Hughes Medical Institute","NHLBI NIH HHS"],"pagination":["3405-10"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3587189"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["110(9)"],"pubmed_abstract":["A goal of regenerative medicine is to identify cardiovascular progenitors from human ES cells (hESCs) that can functionally integrate into the human heart. Previous studies to evaluate the developmental potential of candidate hESC-derived progenitors have delivered these cells into murine and porcine cardiac tissue, with inconclusive evidence regarding the capacity of these human cells to physiologically engraft in xenotransplantation assays. Further, the potential of hESC-derived cardiovascular lineage cells to functionally couple to human myocardium remains untested and unknown. Here, we have prospectively identified a population of hESC-derived ROR2(+)/CD13(+)/KDR(+)/PDGFRα(+) cells that give rise to cardiomyocytes, endothelial cells, and vascular smooth muscle cells in vitro at a clona"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Prospective isolation of human embryonic stem cell-derived cardiovascular progenitors that integrate into human fetal heart tissue."],"pmcid":["PMC3587189"],"funding_grant_id":["5T32 HL00708"],"pubmed_authors":["Ardehali R","Yazawa M","Weissman IL","Abilez OJ","Nusse R","Drukker M","Inlay MA","Blauwkamp TA","Ali SR","Chen MQ","Gong Y"],"additional_accession":[]},"is_claimable":false,"name":"Prospective isolation of human embryonic stem cell-derived cardiovascular progenitors that integrate into human fetal heart tissue.","description":"A goal of regenerative medicine is to identify cardiovascular progenitors from human ES cells (hESCs) that can functionally integrate into the human heart. Previous studies to evaluate the developmental potential of candidate hESC-derived progenitors have delivered these cells into murine and porcine cardiac tissue, with inconclusive evidence regarding the capacity of these human cells to physiologically engraft in xenotransplantation assays. Further, the potential of hESC-derived cardiovascular lineage cells to functionally couple to human myocardium remains untested and unknown. Here, we have prospectively identified a population of hESC-derived ROR2(+)/CD13(+)/KDR(+)/PDGFRα(+) cells that give rise to cardiomyocytes, endothelial cells, and vascular smooth muscle cells in vitro at a clona","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Feb","modification":"2025-04-04T10:36:06.197Z","creation":"2019-03-27T01:05:32Z"},"accession":"S-EPMC3587189","cross_references":{"pubmed":["23391730"],"doi":["10.1073/pnas.1220832110"]}}