biostudies-literaturePervin SNIA NIH HHSNCI NIH HHS848-58https://www.ebi.ac.uk/biostudies/studies/S-EPMC3590675biostudies-literatureUnknown108(4)<h4>Background</h4>Breast cancer, a heterogeneous disease has been broadly classified into oestrogen receptor positive (ER+) or oestrogen receptor negative (ER-) tumour types. Each of these tumours is dependent on specific signalling pathways for their progression. While high levels of survivin, an anti-apoptotic protein, increases aggressive behaviour in ER- breast tumours, oxidative stress (OS) promotes the progression of ER+ breast tumours. Mechanisms and molecular targets by which OS promotes tumourigenesis remain poorly understood.<h4>Results</h4>DETA-NONOate, a nitric oxide (NO)-donor induces OS in breast cancer cell lines by early re-localisation and downregulation of cellular survivin. Using in vivo models of HMLE(HRAS) xenografts and E2-induced breast tumours in ACI rats, we demonBritish journal of cancerOxidative stress specifically downregulates survivin to promote breast tumour formation.PMC3590675U54 CA143931SC1 AG033407-01A11SC1 CA165865-01A1SC1 AG049682SC1 AG033407SC1 CA165865U54CA143931Braga MParveen MChaudhuri GUrman RSingh RTran LPervin SLi SAfalseOxidative stress specifically downregulates survivin to promote breast tumour formation.<h4>Background</h4>Breast cancer, a heterogeneous disease has been broadly classified into oestrogen receptor positive (ER+) or oestrogen receptor negative (ER-) tumour types. Each of these tumours is dependent on specific signalling pathways for their progression. While high levels of survivin, an anti-apoptotic protein, increases aggressive behaviour in ER- breast tumours, oxidative stress (OS) promotes the progression of ER+ breast tumours. Mechanisms and molecular targets by which OS promotes tumourigenesis remain poorly understood.<h4>Results</h4>DETA-NONOate, a nitric oxide (NO)-donor induces OS in breast cancer cell lines by early re-localisation and downregulation of cellular survivin. Using in vivo models of HMLE(HRAS) xenografts and E2-induced breast tumours in ACI rats, we demon2013-01-01T00:00:00Z2013 Mar2026-05-01T05:07:09.928Z2026-04-07T16:40:24.895ZS-EPMC35906752340382010.1038/bjc.2013.40