{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ludwig KU"],"funding":["Medical Research Council"],"pagination":["e229"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3591001"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["3"],"pubmed_abstract":["The ability to perform mathematical tasks is required in everyday life. Although heritability estimates suggest a genetic contribution, no previous study has conclusively identified a genetic risk variant for mathematical performance. Research has shown that the prevalence of mathematical disabilities is increased in children with dyslexia. We therefore correlated genome-wide data of 200 German children with spelling disability, with available quantitative data on mathematic ability. Replication of the top findings in additional dyslexia samples revealed that rs133885 was a genome-wide significant marker for mathematical abilities (P(comb) = 7.71 × 10(-10), n = 699), with an effect size of 4.87%. This association was also found in a sample from the general population (P = 0.048, n = 1080),"],"journal":["Translational psychiatry"],"pubmed_title":["A common variant in myosin-18B contributes to mathematical abilities in children with dyslexia and intraparietal sulcus variability in adults."],"pmcid":["PMC3591001"],"funding_grant_id":["G0500079(73692)","G500079","G9817803B","G0500079"],"pubmed_authors":["Ludwig KU","Becker J","Czisch M","Davis OS","Landerl K","Warnke A","Nothen MM","Plomin R","Alexander M","Czamara D","Docherty SJ","Muller-Myhsok B","Schumacher J","Spieler D","Moll K","Hoffmann P","Samann P","Bruder J","Schulte-Korne G"],"additional_accession":[]},"is_claimable":false,"name":"A common variant in myosin-18B contributes to mathematical abilities in children with dyslexia and intraparietal sulcus variability in adults.","description":"The ability to perform mathematical tasks is required in everyday life. Although heritability estimates suggest a genetic contribution, no previous study has conclusively identified a genetic risk variant for mathematical performance. Research has shown that the prevalence of mathematical disabilities is increased in children with dyslexia. We therefore correlated genome-wide data of 200 German children with spelling disability, with available quantitative data on mathematic ability. Replication of the top findings in additional dyslexia samples revealed that rs133885 was a genome-wide significant marker for mathematical abilities (P(comb) = 7.71 × 10(-10), n = 699), with an effect size of 4.87%. This association was also found in a sample from the general population (P = 0.048, n = 1080),","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Feb","modification":"2026-05-05T10:44:26.695Z","creation":"2026-04-07T21:37:44.917Z"},"accession":"S-EPMC3591001","cross_references":{"pubmed":["23423138"],"doi":["10.1038/tp.2012.148"]}}