biostudies-literatureLudwig KUMedical Research Councile229https://www.ebi.ac.uk/biostudies/studies/S-EPMC3591001biostudies-literatureUnknown3The ability to perform mathematical tasks is required in everyday life. Although heritability estimates suggest a genetic contribution, no previous study has conclusively identified a genetic risk variant for mathematical performance. Research has shown that the prevalence of mathematical disabilities is increased in children with dyslexia. We therefore correlated genome-wide data of 200 German children with spelling disability, with available quantitative data on mathematic ability. Replication of the top findings in additional dyslexia samples revealed that rs133885 was a genome-wide significant marker for mathematical abilities (P(comb) = 7.71 × 10(-10), n = 699), with an effect size of 4.87%. This association was also found in a sample from the general population (P = 0.048, n = 1080),Translational psychiatryA common variant in myosin-18B contributes to mathematical abilities in children with dyslexia and intraparietal sulcus variability in adults.PMC3591001G0500079(73692)G500079G9817803BG0500079Ludwig KUBecker JCzisch MDavis OSLanderl KWarnke ANothen MMPlomin RAlexander MCzamara DDocherty SJMuller-Myhsok BSchumacher JSpieler DMoll KHoffmann PSamann PBruder JSchulte-Korne GfalseA common variant in myosin-18B contributes to mathematical abilities in children with dyslexia and intraparietal sulcus variability in adults.The ability to perform mathematical tasks is required in everyday life. Although heritability estimates suggest a genetic contribution, no previous study has conclusively identified a genetic risk variant for mathematical performance. Research has shown that the prevalence of mathematical disabilities is increased in children with dyslexia. We therefore correlated genome-wide data of 200 German children with spelling disability, with available quantitative data on mathematic ability. Replication of the top findings in additional dyslexia samples revealed that rs133885 was a genome-wide significant marker for mathematical abilities (P(comb) = 7.71 × 10(-10), n = 699), with an effect size of 4.87%. This association was also found in a sample from the general population (P = 0.048, n = 1080),2013-01-01T00:00:00Z2013 Feb2026-05-05T10:44:26.695Z2026-04-07T21:37:44.917ZS-EPMC35910012342313810.1038/tp.2012.148