biostudies-literatureClarke MAustrian Science Fund FWFMedical Research CouncilWellcome TrustBiotechnology and Biological Sciences Research Council661-70https://www.ebi.ac.uk/biostudies/studies/S-EPMC3593183biostudies-literatureUnknown27(3)The haematopoietic system is prone to age-related disorders ranging from deficits in functional blood cells to the development of neoplastic states. Such neoplasms often involve recurrent cytogenetic abnormalities, among which a deletion in the long arm of chromosome 20 (del20q) is common in myeloid malignancies. The del20q minimum deleted region contains nine genes, including MYBL2, which encodes a key protein involved in the maintenance of genome integrity. Here, we show that mice expressing half the normal levels of Mybl2 (Mybl2(+/Δ)) develop a variety of myeloid disorders upon ageing. These include myeloproliferative neoplasms, myelodysplasia (MDS) and myeloid leukaemia, mirroring the human conditions associated with del20q. Moreover, analysis of gene expression profiles from patients LeukemiaMYBL2 haploinsufficiency increases susceptibility to age-related haematopoietic neoplasia.PMC3593183G9818340BP 23257MR/K01076X/1BB/E001459/11092244Jager RDawood BKralovics RFrampton JFreeman SLorvellec MDumon SSheriff LWard CClarke MGarcia PfalseMYBL2 haploinsufficiency increases susceptibility to age-related haematopoietic neoplasia.The haematopoietic system is prone to age-related disorders ranging from deficits in functional blood cells to the development of neoplastic states. Such neoplasms often involve recurrent cytogenetic abnormalities, among which a deletion in the long arm of chromosome 20 (del20q) is common in myeloid malignancies. The del20q minimum deleted region contains nine genes, including MYBL2, which encodes a key protein involved in the maintenance of genome integrity. Here, we show that mice expressing half the normal levels of Mybl2 (Mybl2(+/Δ)) develop a variety of myeloid disorders upon ageing. These include myeloproliferative neoplasms, myelodysplasia (MDS) and myeloid leukaemia, mirroring the human conditions associated with del20q. Moreover, analysis of gene expression profiles from patients 2013-01-01T00:00:00Z2013 Mar2026-04-29T08:13:43.497Z2019-03-27T01:05:51ZS-EPMC35931832291018310.1038/leu.2012.241