{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Elsen GE"],"funding":["NIAID NIH HHS","NINDS NIH HHS"],"pagination":["4081-6"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3593833"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["110(10)"],"pubmed_abstract":["The cortical area map is initially patterned by transcription factor (TF) gradients in the neocortical primordium, which define a \"protomap\" in the embryonic ventricular zone (VZ). However, mechanisms that propagate regional identity from VZ progenitors to cortical plate (CP) neurons are unknown. Here we show that the VZ, subventricular zone (SVZ), and CP contain distinct molecular maps of regional identity, reflecting different gene expression gradients in radial glia progenitors, intermediate progenitors, and projection neurons, respectively. The \"intermediate map\" in the SVZ is modulated by Eomes (also known as Tbr2), a T-box TF. Eomes inactivation caused rostrocaudal shifts in SVZ and CP gene expression, with loss of corticospinal axons and gain of corticotectal projections. These find"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["The protomap is propagated to cortical plate neurons through an Eomes-dependent intermediate map."],"pmcid":["PMC3593833"],"funding_grant_id":["R01 AI061699","R01 NS050248","NS050248"],"pubmed_authors":["Hodge RD","Shiba N","Elsen GE","Bedogni F","Daza RA","Reiner SL","Nelson BR","Hevner RF"],"additional_accession":[]},"is_claimable":false,"name":"The protomap is propagated to cortical plate neurons through an Eomes-dependent intermediate map.","description":"The cortical area map is initially patterned by transcription factor (TF) gradients in the neocortical primordium, which define a \"protomap\" in the embryonic ventricular zone (VZ). However, mechanisms that propagate regional identity from VZ progenitors to cortical plate (CP) neurons are unknown. Here we show that the VZ, subventricular zone (SVZ), and CP contain distinct molecular maps of regional identity, reflecting different gene expression gradients in radial glia progenitors, intermediate progenitors, and projection neurons, respectively. The \"intermediate map\" in the SVZ is modulated by Eomes (also known as Tbr2), a T-box TF. Eomes inactivation caused rostrocaudal shifts in SVZ and CP gene expression, with loss of corticospinal axons and gain of corticotectal projections. These find","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Mar","modification":"2026-04-30T23:21:30.729Z","creation":"2026-04-07T16:27:35.082Z"},"accession":"S-EPMC3593833","cross_references":{"pubmed":["23431145"],"doi":["10.1073/pnas.1209076110"]}}