{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Schvarzstein M"],"funding":["NIGMS NIH HHS","CIHR"],"pagination":["E898-907"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3593872"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["110(10)"],"pubmed_abstract":["In many species where oocytes lack centrosomes, sperm contribute both genetic material and centriole(s) to the zygote. Correct centriole organization during male meiosis is critical to guarantee a normal bipolar mitotic spindle in the zygote. During Caenorhabditis elegans male meiosis, centrioles normally undergo two rounds of duplication, resulting in haploid sperm each containing a single tightly engaged centriole pair. Here we identify an unanticipated role for C. elegans HORMA (Hop1/Rev7/Mad2) domain proteins HTP-1/2 and HIM-3 in regulating centriole disengagement during spermatocyte meiosis. In him-3 and htp-1 htp-2 mutants, centrioles separate inappropriately during meiosis II, resulting in spermatids with disengaged centrioles. Moreover, extra centrosomes are detected in a subset of"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Meiotic HORMA domain proteins prevent untimely centriole disengagement during Caenorhabditis elegans spermatocyte meiosis."],"pmcid":["PMC3593872"],"funding_grant_id":["R01 GM053804","R01 GM53804"],"pubmed_authors":["Villeneuve AM","Pattabiraman D","Bembenek JN","Schvarzstein M"],"additional_accession":[]},"is_claimable":false,"name":"Meiotic HORMA domain proteins prevent untimely centriole disengagement during Caenorhabditis elegans spermatocyte meiosis.","description":"In many species where oocytes lack centrosomes, sperm contribute both genetic material and centriole(s) to the zygote. Correct centriole organization during male meiosis is critical to guarantee a normal bipolar mitotic spindle in the zygote. During Caenorhabditis elegans male meiosis, centrioles normally undergo two rounds of duplication, resulting in haploid sperm each containing a single tightly engaged centriole pair. Here we identify an unanticipated role for C. elegans HORMA (Hop1/Rev7/Mad2) domain proteins HTP-1/2 and HIM-3 in regulating centriole disengagement during spermatocyte meiosis. In him-3 and htp-1 htp-2 mutants, centrioles separate inappropriately during meiosis II, resulting in spermatids with disengaged centrioles. Moreover, extra centrosomes are detected in a subset of","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Mar","modification":"2025-04-19T09:06:02.254Z","creation":"2019-03-27T01:05:53Z"},"accession":"S-EPMC3593872","cross_references":{"pubmed":["23401519"],"doi":["10.1073/pnas.1213888110"]}}