{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(2)"],"submitter":["Magbanua E"],"pubmed_abstract":["Aptamers are oligonucleotides that bind targets with high specificity and affinity. They have become important tools for biosensing, target detection, drug delivery and therapy. We selected the quadruplex-forming 16-mer DNA aptamer AID-1 [d(GGGT) 4] with affinity for the interleukin-6 receptor (IL-6R) and identified single nucleotide variants that showed no significant loss of binding ability. The RNA counterpart of AID-1 [r(GGGU) 4] also bound IL-6R as quadruplex structure. AID-1 is identical to the well-known HIV inhibitor T30923, which inhibits both HIV infection and HIV-1 integrase. We also demonstrated that IL-6R specific RNA aptamers not only bind HIV-1 integrase and inhibit its 3' processing activity in vitro, but also are capable of preventing HIV de novo infection with the same ef"],"journal":["RNA biology"],"pagination":["216-27"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3594281"],"repository":["biostudies-literature"],"pubmed_title":["d(GGGT) 4 and r(GGGU) 4 are both HIV-1 inhibitors and interleukin-6 receptor aptamers."],"pmcid":["PMC3594281"],"pubmed_authors":["Meyer C","Hahn U","Hauber J","Hansen B","Lorenzen I","Magbanua E","Rose-John S","Mayer G","Zivkovic T","Grotzinger J","Torda AE","Beschorner N"],"additional_accession":[]},"is_claimable":false,"name":"d(GGGT) 4 and r(GGGU) 4 are both HIV-1 inhibitors and interleukin-6 receptor aptamers.","description":"Aptamers are oligonucleotides that bind targets with high specificity and affinity. They have become important tools for biosensing, target detection, drug delivery and therapy. We selected the quadruplex-forming 16-mer DNA aptamer AID-1 [d(GGGT) 4] with affinity for the interleukin-6 receptor (IL-6R) and identified single nucleotide variants that showed no significant loss of binding ability. The RNA counterpart of AID-1 [r(GGGU) 4] also bound IL-6R as quadruplex structure. AID-1 is identical to the well-known HIV inhibitor T30923, which inhibits both HIV infection and HIV-1 integrase. We also demonstrated that IL-6R specific RNA aptamers not only bind HIV-1 integrase and inhibit its 3' processing activity in vitro, but also are capable of preventing HIV de novo infection with the same ef","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Feb","modification":"2026-04-30T23:32:51.969Z","creation":"2019-03-27T01:05:55Z"},"accession":"S-EPMC3594281","cross_references":{"pubmed":["23235494"],"doi":["10.4161/rna.22951"]}}