{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(3)"],"submitter":["Zhao Y"],"pubmed_abstract":["<h4>Introduction</h4>Variations in genetic background are the leading cause of differential susceptibility to traumatic infection. Heat shock protein 90 (HSP90), a broadly distributed and conserved molecule, regulates inflammation under stressful and traumatic conditions. However, the relationships between HSP90 genetic polymorphisms, post-traumatic inflammatory responses and organ function remain unknown.<h4>Methods</h4>A total of 286 healthy volunteers and patients with severe trauma took part in a single nucleotide polymorphism (SNP)-based analysis of the HSP90beta gene and a clinical association analysis. HSP90beta and TNF-alpha levels were determined using quantitative PCR and western blot. The transcriptional activity of the HSP90beta promoter was assayed using the Dual-Luciferase Re"],"journal":["PloS one"],"pagination":["e58646"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3596273"],"repository":["biostudies-literature"],"pubmed_title":["The -144C/A polymorphism in the promoter of HSP90beta is associated with multiple organ dysfunction scores."],"pmcid":["PMC3596273"],"pubmed_authors":["Zhou YG","Peng Y","Tao L","Ning Y","Liu P","Li P","Xiong R","Jiang D","Chen X","Zhao Y"],"additional_accession":[]},"is_claimable":false,"name":"The -144C/A polymorphism in the promoter of HSP90beta is associated with multiple organ dysfunction scores.","description":"<h4>Introduction</h4>Variations in genetic background are the leading cause of differential susceptibility to traumatic infection. Heat shock protein 90 (HSP90), a broadly distributed and conserved molecule, regulates inflammation under stressful and traumatic conditions. However, the relationships between HSP90 genetic polymorphisms, post-traumatic inflammatory responses and organ function remain unknown.<h4>Methods</h4>A total of 286 healthy volunteers and patients with severe trauma took part in a single nucleotide polymorphism (SNP)-based analysis of the HSP90beta gene and a clinical association analysis. HSP90beta and TNF-alpha levels were determined using quantitative PCR and western blot. The transcriptional activity of the HSP90beta promoter was assayed using the Dual-Luciferase Re","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013","modification":"2025-04-05T16:10:57.154Z","creation":"2019-03-26T23:13:44Z"},"accession":"S-EPMC3596273","cross_references":{"pubmed":["23516526"],"doi":["10.1371/journal.pone.0058646"]}}