biostudies-literatureUnknown8(3)Zhao Y<h4>Introduction</h4>Variations in genetic background are the leading cause of differential susceptibility to traumatic infection. Heat shock protein 90 (HSP90), a broadly distributed and conserved molecule, regulates inflammation under stressful and traumatic conditions. However, the relationships between HSP90 genetic polymorphisms, post-traumatic inflammatory responses and organ function remain unknown.<h4>Methods</h4>A total of 286 healthy volunteers and patients with severe trauma took part in a single nucleotide polymorphism (SNP)-based analysis of the HSP90beta gene and a clinical association analysis. HSP90beta and TNF-alpha levels were determined using quantitative PCR and western blot. The transcriptional activity of the HSP90beta promoter was assayed using the Dual-Luciferase RePloS onee58646https://www.ebi.ac.uk/biostudies/studies/S-EPMC3596273biostudies-literatureThe -144C/A polymorphism in the promoter of HSP90beta is associated with multiple organ dysfunction scores.PMC3596273Zhou YGPeng YTao LNing YLiu PLi PXiong RJiang DChen XZhao YfalseThe -144C/A polymorphism in the promoter of HSP90beta is associated with multiple organ dysfunction scores.<h4>Introduction</h4>Variations in genetic background are the leading cause of differential susceptibility to traumatic infection. Heat shock protein 90 (HSP90), a broadly distributed and conserved molecule, regulates inflammation under stressful and traumatic conditions. However, the relationships between HSP90 genetic polymorphisms, post-traumatic inflammatory responses and organ function remain unknown.<h4>Methods</h4>A total of 286 healthy volunteers and patients with severe trauma took part in a single nucleotide polymorphism (SNP)-based analysis of the HSP90beta gene and a clinical association analysis. HSP90beta and TNF-alpha levels were determined using quantitative PCR and western blot. The transcriptional activity of the HSP90beta promoter was assayed using the Dual-Luciferase Re2013-01-01T00:00:00Z20132025-04-05T16:10:57.154Z2019-03-26T23:13:44ZS-EPMC35962732351652610.1371/journal.pone.0058646