{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["168(6)"],"submitter":["Cho DI"],"pubmed_abstract":["<h4>Background and purpose</h4>GPCRs undergo both homologous and heterologous regulatory processes in which receptor phosphorylation plays a critical role. The protein kinases responsible for each pathway are well established; however, other molecular details that characterize each pathway remain unclear. In this study, the molecular mechanisms that determine the differences in the functional roles and intracellular trafficking between homologous and PKC-mediated heterologous internalization pathways for the dopamine D₂ receptor were investigated.<h4>Experimental approach</h4>All of the S/T residues located within the intracellular loops of D₂ receptor were mutated, and the residues responsible for GRK- and PKC-mediated internalization were determined in HEK-293 cells and SH-SY5Y cells. Th"],"journal":["British journal of pharmacology"],"pagination":["1355-74"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3596642"],"repository":["biostudies-literature"],"pubmed_title":["ARF6 and GASP-1 are post-endocytic sorting proteins selectively involved in the intracellular trafficking of dopamine D₂ receptors mediated by GRK and PKC in transfected cells."],"pmcid":["PMC3596642"],"pubmed_authors":["Choi HK","Zheng M","Kwon KJ","Kim KM","Cho DI","Min C","Shin CY"],"additional_accession":[]},"is_claimable":false,"name":"ARF6 and GASP-1 are post-endocytic sorting proteins selectively involved in the intracellular trafficking of dopamine D₂ receptors mediated by GRK and PKC in transfected cells.","description":"<h4>Background and purpose</h4>GPCRs undergo both homologous and heterologous regulatory processes in which receptor phosphorylation plays a critical role. The protein kinases responsible for each pathway are well established; however, other molecular details that characterize each pathway remain unclear. In this study, the molecular mechanisms that determine the differences in the functional roles and intracellular trafficking between homologous and PKC-mediated heterologous internalization pathways for the dopamine D₂ receptor were investigated.<h4>Experimental approach</h4>All of the S/T residues located within the intracellular loops of D₂ receptor were mutated, and the residues responsible for GRK- and PKC-mediated internalization were determined in HEK-293 cells and SH-SY5Y cells. Th","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Mar","modification":"2026-07-16T22:42:28.596Z","creation":"2019-03-27T01:06:02Z"},"accession":"S-EPMC3596642","cross_references":{"pubmed":["23082996"],"doi":["10.1111/bph.12025"]}}