biostudies-literatureUnknown13da Silva ER<h4>Background</h4>Lower respiratory tract infection (LRTI) is a major cause of pediatric morbidity and mortality, especially among non-affluent communities. In this study we determine the impact of respiratory viruses and how viral co-detections/infections can affect clinical LRTI severity in children in a hospital setting.<h4>Methods</h4>Patients younger than 3 years of age admitted to a tertiary hospital in Brazil during the months of high prevalence of respiratory viruses had samples collected from nasopharyngeal aspiration. These samples were tested for 13 different respiratory viruses through real-time PCR (rt-PCR). Patients were followed during hospitalization, and clinical data and population characteristics were collected during that period and at discharge to evaluate severity maBMC infectious diseases41https://www.ebi.ac.uk/biostudies/studies/S-EPMC3598993biostudies-literatureSevere lower respiratory tract infection in infants and toddlers from a non-affluent population: viral etiology and co-detection as risk factors.PMC3598993Cintra Oda Silva ERStein RTMattiello RJones MHde Paula FEDelcaro LSRibeiro JDPitrez MCProenca-Modena JLArruda ESarria EEfalseSevere lower respiratory tract infection in infants and toddlers from a non-affluent population: viral etiology and co-detection as risk factors.<h4>Background</h4>Lower respiratory tract infection (LRTI) is a major cause of pediatric morbidity and mortality, especially among non-affluent communities. In this study we determine the impact of respiratory viruses and how viral co-detections/infections can affect clinical LRTI severity in children in a hospital setting.<h4>Methods</h4>Patients younger than 3 years of age admitted to a tertiary hospital in Brazil during the months of high prevalence of respiratory viruses had samples collected from nasopharyngeal aspiration. These samples were tested for 13 different respiratory viruses through real-time PCR (rt-PCR). Patients were followed during hospitalization, and clinical data and population characteristics were collected during that period and at discharge to evaluate severity ma2013-01-01T00:00:00Z2013 Jan2026-07-15T17:32:09.54Z2026-07-07T03:09:49.526ZS-EPMC35989932335111710.1186/1471-2334-13-41