{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Malfait AM"],"funding":["NIAMS NIH HHS"],"pagination":["1042-8"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3603144"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["71(6)"],"pubmed_abstract":["Objectives
The aim of this study was to assess if genetic variation in the PACE4 (paired amino acid converting enzyme 4) gene Pcsk6 influences the risk for symptomatic knee osteoarthritis (OA).Methods
Ten PCSK6 single nucleotide polymorphisms were tested for association in a discovery cohort of radiographic knee OA (n=156 asymptomatic and 600 symptomatic cases). Meta-analysis of the minor allele at rs900414 was performed in three additional independent cohorts (total n=674 asymptomatic and 2068 symptomatic). Pcsk6 knockout mice and wild-type C57BL/6 mice were compared in a battery of algesiometric assays, including hypersensitivity in response to intraplantar substance P, pain behaviours in response to intrathecal substance P and pain behaviour in the abdominal constriction"],"journal":["Annals of the rheumatic diseases"],"pubmed_title":["A role for PACE4 in osteoarthritis pain: evidence from human genetic association and null mutant phenotype."],"pmcid":["PMC3603144"],"funding_grant_id":["R01AR060364-01","R01 AR060364"],"pubmed_authors":["Valdes AM","Das R","Seymour AB","Wood LS","Sorge RE","Le Graverand-Gastineau MP","Leaverton PE","Hart DJ","Mogil JS","Malfait AM","Doherty S","Gao F","Sotocinal SG","Schorscher-Petcu A","Tortorella MD","Zhang W","Doherty M","Vaughn FL","Muir KR","Spector TD","Arden NK","Maciewicz RA"],"additional_accession":[]},"is_claimable":false,"name":"A role for PACE4 in osteoarthritis pain: evidence from human genetic association and null mutant phenotype.","description":"Objectives
The aim of this study was to assess if genetic variation in the PACE4 (paired amino acid converting enzyme 4) gene Pcsk6 influences the risk for symptomatic knee osteoarthritis (OA).Methods
Ten PCSK6 single nucleotide polymorphisms were tested for association in a discovery cohort of radiographic knee OA (n=156 asymptomatic and 600 symptomatic cases). Meta-analysis of the minor allele at rs900414 was performed in three additional independent cohorts (total n=674 asymptomatic and 2068 symptomatic). Pcsk6 knockout mice and wild-type C57BL/6 mice were compared in a battery of algesiometric assays, including hypersensitivity in response to intraplantar substance P, pain behaviours in response to intrathecal substance P and pain behaviour in the abdominal constriction","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Jun","modification":"2026-05-02T18:26:55.538Z","creation":"2026-04-07T18:19:43.025Z"},"accession":"S-EPMC3603144","cross_references":{"pubmed":["22440827"],"doi":["10.1136/annrheumdis-2011-200300"]}}