{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kapil V"],"funding":["British Heart Foundation"],"pagination":["93-100"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3605573"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["55"],"pubmed_abstract":["Circulating nitrate (NO(3)(-)), derived from dietary sources or endogenous nitric oxide production, is extracted from blood by the salivary glands, accumulates in saliva, and is then reduced to nitrite (NO(2)(-)) by the oral microflora. This process has historically been viewed as harmful, because nitrite can promote formation of potentially carcinogenic N-nitrosamines. More recent research, however, suggests that nitrite can also serve as a precursor for systemic generation of vasodilatory nitric oxide, and exogenous administration of nitrate reduces blood pressure in humans. However, whether oral nitrate-reducing bacteria participate in \"setting\" blood pressure is unknown. We investigated whether suppression of the oral microflora affects systemic nitrite levels and hence blood pressure "],"journal":["Free radical biology & medicine"],"pubmed_title":["Physiological role for nitrate-reducing oral bacteria in blood pressure control."],"pmcid":["PMC3605573"],"funding_grant_id":["SP/08/006/25110"],"pubmed_authors":["Pearl V","Ahluwalia A","Kapil V","Haydar SM","Lundberg JO","Weitzberg E"],"additional_accession":[]},"is_claimable":false,"name":"Physiological role for nitrate-reducing oral bacteria in blood pressure control.","description":"Circulating nitrate (NO(3)(-)), derived from dietary sources or endogenous nitric oxide production, is extracted from blood by the salivary glands, accumulates in saliva, and is then reduced to nitrite (NO(2)(-)) by the oral microflora. This process has historically been viewed as harmful, because nitrite can promote formation of potentially carcinogenic N-nitrosamines. More recent research, however, suggests that nitrite can also serve as a precursor for systemic generation of vasodilatory nitric oxide, and exogenous administration of nitrate reduces blood pressure in humans. However, whether oral nitrate-reducing bacteria participate in \"setting\" blood pressure is unknown. We investigated whether suppression of the oral microflora affects systemic nitrite levels and hence blood pressure ","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Feb","modification":"2025-04-25T21:58:15.659Z","creation":"2019-03-27T01:06:28Z"},"accession":"S-EPMC3605573","cross_references":{"pubmed":["23183324"],"doi":["10.1016/j.freeradbiomed.2012.11.013"]}}