biostudies-literatureJahanshad NNIBIB NIH HHSNICHD NIH HHSNIA NIH HHSNIMH NIH HHSNHGRI NIH HHSNLM NIH HHSNINDS NIH HHS4768-73https://www.ebi.ac.uk/biostudies/studies/S-EPMC3606977biostudies-literatureUnknown110(12)Aberrant connectivity is implicated in many neurological and psychiatric disorders, including Alzheimer's disease and schizophrenia. However, other than a few disease-associated candidate genes, we know little about the degree to which genetics play a role in the brain networks; we know even less about specific genes that influence brain connections. Twin and family-based studies can generate estimates of overall genetic influences on a trait, but genome-wide association scans (GWASs) can screen the genome for specific variants influencing the brain or risk for disease. To identify the heritability of various brain connections, we scanned healthy young adult twins with high-field, high-angular resolution diffusion MRI. We adapted GWASs to screen the brain's connectivity pattern, allowing uProceedings of the National Academy of Sciences of the United States of AmericaGenome-wide scan of healthy human connectome discovers SPON1 gene variant influencing dementia severity.PMC3606977P50 AG005138K24 AG027841P50 AG008702P30 AG013846P41 EB015922T15 LM07356R01 EB008281U01 HG006500R01 MH097268HG006500AG027841U24 AG021886HG002213T15 LM007356R01 EB007813R01 AG040060R01 HG002213R01 NS080655R01 HD050735R01 EB008432Crawford KCarmichael OMartin NGLee VMTaylor JLMcMahon KLGrossman HBrewer JRosen HJRajagopalan PLane BChertkow HDeCarli CLeon SLord JLMontine TVillanueva-Meyer JWolk DTaylor-Reinwald LPetrella JRHua XMathis CRachinsky IFrank RDuara RWatkins FReeder Sde Leon MJCelmins DWu CKPawluczyk SRomirowsky AFletcher ELah JJHsiung GYDeVous MMunic DSalloway SKarlawish JHMintun MATurner RSCapote HNeu SFeldman HKhachaturian ZJohnson KANir TMLee TYDoraiswamy PMBernick CPreda AAsthana SAisen PHosein COtt BRBurns JMMacAvoy MGQuinn JHansell NKSmith CDMintzer JRoberts PTrojanowski JQSwerdlow RHTremont GKoeppe RAVaron DHibar DPMedland SEJicha GReynolds BKowall NGreen RCReiman EMdeToledo-Morrell LChen KBrand CSilverman DHBell KLCarlsson CMZimmerman EAFleisher ASadowsky CAnderson HSThompson PMPorsteinsson APMiller BLJohnson KJohnson NSchuff NJohnson SDiaz-Arrastia RRusinek HMartinez WKertesz AHonig LSShah RCLerner AMorris JKerwin DLind BVillena TWright MJJohnson HSaykin AJJagust WGamst AMontgomery GWDale AHeidebrink JLGessert DRosen AScharre DWAlbert MAnderson KApostolova LPotkin SGThompson PBandy DBelden CKittur SLiu ESchwartz ESFinger EPetersen RShen LKornak JBudson AEClark DTinklenberg JOnyike CFox NVanderswag HIsmail MSMartin KSather TFrey MSpann BMStern YBartzokis GKaye JSabbagh MBartha RMitsis ENorbash ATrost DWalter SKielb SJacobson SBernstein MKilliany RMolchan SKataki MCairns NJQuiceno MDrost DOakley MToga AWSantulli RBFelmlee JShaw LLongmire CFHake AMForoud TMYesavage JSchneider SWeiner MSnyder PJBlank KArnold SESperling RACarson REHudson LBlack SRainka MCaldwell CPearlson GDFarlow MRMudge BBeckett LCarroll MJack CRHerring SLopez OLMesulam MMLipowski KGraff-Radford NRDolen SWolday SFoster NOgrocki Pvan Dyck CHQuerfurth HMulnard RAStefanovic BMalloy PGriffith RBates VLu PHGarg PMc-Adams-Ortiz Cde Zubicaray GIMarson DGlodzik LWeiner MWSimpson DMWilliamson JDKorecka MColeman REHarvey DDe Santi SCorreia SWomack KHardy PMartin-Cook KMathews DMatthews BRAnces BDoody RSChowdhury MAlzheimer’s Disease Neuroimaging InitiativeBrown ADAlexander GPotkin SBorrie MBergman HOlichney JRogers JThai GMakino KMKing RCellar JSBwayo SKJahanshad NSchneider LSSpicer KLevey AIObisesan TOTrojanowki JQMarshall GParfitt FDonohue MMorris JCJohnson PLNguyen DAssaly MTariot PGoldstein BSSink KMThomas RGfalseGenome-wide scan of healthy human connectome discovers SPON1 gene variant influencing dementia severity.Aberrant connectivity is implicated in many neurological and psychiatric disorders, including Alzheimer's disease and schizophrenia. However, other than a few disease-associated candidate genes, we know little about the degree to which genetics play a role in the brain networks; we know even less about specific genes that influence brain connections. Twin and family-based studies can generate estimates of overall genetic influences on a trait, but genome-wide association scans (GWASs) can screen the genome for specific variants influencing the brain or risk for disease. To identify the heritability of various brain connections, we scanned healthy young adult twins with high-field, high-angular resolution diffusion MRI. We adapted GWASs to screen the brain's connectivity pattern, allowing u2013-01-01T00:00:00Z2013 Mar2026-05-05T10:33:11.866Z2026-04-07T21:37:33.144ZS-EPMC36069772347198510.1073/pnas.1216206110