biostudies-literatureUnknown13Felix J<h4>Background</h4>Supporting health care sector decisions using time-dependent endpoints (TDEs) such as time to progression (TTP), progression-free survival (PFS), and event-free survival (EFS) remains controversial. This study estimated the quantitative relationship between median TDE and median overall survival (OS) in multiple myeloma (MM) patients.<h4>Methods</h4>Studies (excluding allogeneic transplantation) published from 1970 to 2011 were systematically searched (PubMed). The nonparametric Spearman's rank correlation coefficient measured the association between median TDE and OS. The quantitative relationship between TDEs and OS was estimated with a two-step approach to a simultaneous Tobit model.<h4>Results</h4>We identified 153 studies: 230 treatment arms, 22,696 patients and meaBMC cancer122https://www.ebi.ac.uk/biostudies/studies/S-EPMC3607860biostudies-literatureTime-dependent endpoints as predictors of overall survival in multiple myeloma.PMC3607860Calado FJRodrigues RFerreira DAlmeida JMRijo JFFelix JAragao FParreira ABfalseTime-dependent endpoints as predictors of overall survival in multiple myeloma.<h4>Background</h4>Supporting health care sector decisions using time-dependent endpoints (TDEs) such as time to progression (TTP), progression-free survival (PFS), and event-free survival (EFS) remains controversial. This study estimated the quantitative relationship between median TDE and median overall survival (OS) in multiple myeloma (MM) patients.<h4>Methods</h4>Studies (excluding allogeneic transplantation) published from 1970 to 2011 were systematically searched (PubMed). The nonparametric Spearman's rank correlation coefficient measured the association between median TDE and OS. The quantitative relationship between TDEs and OS was estimated with a two-step approach to a simultaneous Tobit model.<h4>Results</h4>We identified 153 studies: 230 treatment arms, 22,696 patients and mea2013-01-01T00:00:00Z2013 Mar2025-04-18T14:15:56.019Z2019-03-27T01:06:36ZS-EPMC36078602349736310.1186/1471-2407-13-122