{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["3"],"submitter":["Liu G"],"pubmed_abstract":["Long-term strain improvements through repeated mutagenesis and screening have generated a hyper-producer of cellulases and hemicellulases from Penicillium decumbens 114 which was isolated 30 years ago. Here, the genome of the hyper-producer P. decumbens JU-A10-T was sequenced and compared with that of the wild-type strain 114-2. Further, the transcriptomes and secretomes were compared between the strains. Selective hyper-production of cellulases and hemicellulases but not all the secreted proteins was observed in the mutant, making it a more specific producer of lignocellulolytic enzymes. Functional analysis identified that changes in several transcriptional regulatory elements played crucial roles in the cellulase hyper-producing characteristics of the mutant. Additionally, the mutant sho"],"journal":["Scientific reports"],"pagination":["1569"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3610096"],"repository":["biostudies-literature"],"pubmed_title":["Long-term strain improvements accumulate mutations in regulatory elements responsible for hyper-production of cellulolytic enzymes."],"pmcid":["PMC3610096"],"pubmed_authors":["Ma L","Zhang J","Wang C","Qin Y","Wei X","Liu R","Zhang L","Zou G","Wang L","Liu W","Zheng K","Zheng H","Xun L","Wang S","Wang T","Qu Y","Li J","Chen M","Chen L","Bao X","Zhong Y","Xu H","Yan X","Zhou Z","Fang X","Li Z","Liu G","Zhao GP"],"additional_accession":[]},"is_claimable":false,"name":"Long-term strain improvements accumulate mutations in regulatory elements responsible for hyper-production of cellulolytic enzymes.","description":"Long-term strain improvements through repeated mutagenesis and screening have generated a hyper-producer of cellulases and hemicellulases from Penicillium decumbens 114 which was isolated 30 years ago. Here, the genome of the hyper-producer P. decumbens JU-A10-T was sequenced and compared with that of the wild-type strain 114-2. Further, the transcriptomes and secretomes were compared between the strains. Selective hyper-production of cellulases and hemicellulases but not all the secreted proteins was observed in the mutant, making it a more specific producer of lignocellulolytic enzymes. Functional analysis identified that changes in several transcriptional regulatory elements played crucial roles in the cellulase hyper-producing characteristics of the mutant. Additionally, the mutant sho","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013","modification":"2026-04-29T19:22:02.505Z","creation":"2026-04-07T15:26:16.941Z"},"accession":"S-EPMC3610096","cross_references":{"pubmed":["23535838"],"doi":["10.1038/srep01569"]}}