{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(3)"],"submitter":["Rawat M"],"pubmed_abstract":["<h4>Introduction</h4>Plasmepsin V (PM-V) have functionally conserved orthologues across the Plasmodium genus who's binding and antigenic processing at the PEXEL motifs for export about 200-300 essential proteins is important for the virulence and viability of the causative Plasmodium species. This study was undertaken to determine P. vivax plasmepsin V Ind (PvPM-V-Ind) PEXEL motif export pathway for pathogenicity-related proteins/antigens export thereby altering plasmodium exportome during erythrocytic stages.<h4>Method</h4>We identify and characterize Plasmodium vivax plasmepsin-V-Ind (mutant) gene by cloning, sequence analysis, in silico bioinformatic protocols and structural modeling predictions based on docking studies on binding capacity with PEXEL motifs processing in terms of bindin"],"journal":["PloS one"],"pagination":["e60077"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3612065"],"repository":["biostudies-literature"],"pubmed_title":["Imperfect duplicate insertions type of mutations in plasmepsin V modulates binding properties of PEXEL motifs of export proteins in Indian Plasmodium vivax."],"pmcid":["PMC3612065"],"pubmed_authors":["Sharma A","Rawat M","Tiwari PK","Gupta Y","Vijay S"],"additional_accession":[]},"is_claimable":false,"name":"Imperfect duplicate insertions type of mutations in plasmepsin V modulates binding properties of PEXEL motifs of export proteins in Indian Plasmodium vivax.","description":"<h4>Introduction</h4>Plasmepsin V (PM-V) have functionally conserved orthologues across the Plasmodium genus who's binding and antigenic processing at the PEXEL motifs for export about 200-300 essential proteins is important for the virulence and viability of the causative Plasmodium species. This study was undertaken to determine P. vivax plasmepsin V Ind (PvPM-V-Ind) PEXEL motif export pathway for pathogenicity-related proteins/antigens export thereby altering plasmodium exportome during erythrocytic stages.<h4>Method</h4>We identify and characterize Plasmodium vivax plasmepsin-V-Ind (mutant) gene by cloning, sequence analysis, in silico bioinformatic protocols and structural modeling predictions based on docking studies on binding capacity with PEXEL motifs processing in terms of bindin","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013","modification":"2025-04-19T09:17:00.676Z","creation":"2019-03-26T23:13:58Z"},"accession":"S-EPMC3612065","cross_references":{"pubmed":["23555891"],"doi":["10.1371/journal.pone.0060077"]}}