{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(4)"],"submitter":["Yoo HS"],"pubmed_abstract":["PAF complex (PAFc) is an RNA polymerase II associated factor that controls diverse steps of transcription. Although it is generally associated with actively transcribed genes, a repressive PAFc has also been suggested. Here, we report that PAFc regulates the transition from transcription initiation to transcription elongation. PAFc repressed IL-6-induced, but not TNF-α-induced, immediate early gene expression. PAFc constitutively associated with the 5'-coding region of the c-Fos locus, then transiently dissociated upon IL-6 stimulation. When CTR9, a component of PAFc, was depleted, higher levels of serine 5-phosphorylated or serine 2-phosphorylated forms of RNA Polymerase II were associated with the unstimulated c-Fos locus. We also observed an increased association of CDK9, a kinase compo"],"journal":["PloS one"],"pagination":["e61055"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3623864"],"repository":["biostudies-literature"],"pubmed_title":["CTR9, a component of PAF complex, controls elongation block at the c-Fos locus via signal-dependent regulation of chromatin-bound NELF dissociation."],"pmcid":["PMC3623864"],"pubmed_authors":["Seo JH","Yoo JY","Yoo HS"],"additional_accession":[]},"is_claimable":false,"name":"CTR9, a component of PAF complex, controls elongation block at the c-Fos locus via signal-dependent regulation of chromatin-bound NELF dissociation.","description":"PAF complex (PAFc) is an RNA polymerase II associated factor that controls diverse steps of transcription. Although it is generally associated with actively transcribed genes, a repressive PAFc has also been suggested. Here, we report that PAFc regulates the transition from transcription initiation to transcription elongation. PAFc repressed IL-6-induced, but not TNF-α-induced, immediate early gene expression. PAFc constitutively associated with the 5'-coding region of the c-Fos locus, then transiently dissociated upon IL-6 stimulation. When CTR9, a component of PAFc, was depleted, higher levels of serine 5-phosphorylated or serine 2-phosphorylated forms of RNA Polymerase II were associated with the unstimulated c-Fos locus. We also observed an increased association of CDK9, a kinase compo","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013","modification":"2025-04-26T21:07:08.635Z","creation":"2019-03-26T23:14:06Z"},"accession":"S-EPMC3623864","cross_references":{"pubmed":["23593388"],"doi":["10.1371/journal.pone.0061055"]}}