biostudies-literatureMark TNCI NIH HHS654-60https://www.ebi.ac.uk/biostudies/studies/S-EPMC3626496biostudies-literatureUnknown143(5)The M-protein is the major reference measure for response in multiple myeloma (MM) and its correct interpretation is key to clinical management. The emergence of oligoclonal banding is recognized as a benign finding in the postautologous stem cell transplantation setting (ASCT) for MM but its significance during non-myeloablative therapy is unknown. In a study of the immunomodulatory combination BiRD, (lenalidomide and dexamethasone with clarithromycin), we frequently detected the emergence of mono- and oligo-clonal immunoglobulins unrelated to the baseline diagnostic M-protein. The new M-proteins seen on serum immunofixation electrophoresis were clearly different in either heavy or light chain component(s) from the original M-spike protein and were termed atypical serum immunofixation patBritish journal of haematologyAtypical serum immunofixation patterns frequently emerge in immunomodulatory therapy and are associated with a high degree of response in multiple myeloma.PMC3626496K23 CA109260K23 CA109260-01Agrawal YPLent RPearse RNFurman RRChristos PJMatthew SLee JWCesarman EMark TColeman MWang YLNiesvizky RChen-Kiang SMazumdar MEly SLeonard JPJayabalan DfalseAtypical serum immunofixation patterns frequently emerge in immunomodulatory therapy and are associated with a high degree of response in multiple myeloma.The M-protein is the major reference measure for response in multiple myeloma (MM) and its correct interpretation is key to clinical management. The emergence of oligoclonal banding is recognized as a benign finding in the postautologous stem cell transplantation setting (ASCT) for MM but its significance during non-myeloablative therapy is unknown. In a study of the immunomodulatory combination BiRD, (lenalidomide and dexamethasone with clarithromycin), we frequently detected the emergence of mono- and oligo-clonal immunoglobulins unrelated to the baseline diagnostic M-protein. The new M-proteins seen on serum immunofixation electrophoresis were clearly different in either heavy or light chain component(s) from the original M-spike protein and were termed atypical serum immunofixation pat2008-01-01T00:00:00Z2008 Dec2025-04-03T23:57:54.966Z2019-03-27T01:07:25ZS-EPMC36264961895046110.1111/j.1365-2141.2008.07374.x