{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["May RM"],"funding":["NIAID NIH HHS","NHLBI NIH HHS","NCI NIH HHS","NIAMS NIH HHS"],"pagination":["3135-46"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3630829"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["121(16)"],"pubmed_abstract":["Signaling pathways leading to natural killer (NK)-cell effector function are complex and incompletely understood. Here, we investigated the proximal signaling pathways downstream of the immunotyrosine-based activation motif (ITAM) bearing activating receptors. We found that the adaptor molecule SH2 domain-containing leukocyte protein of 76 kD (SLP-76) is recruited to microclusters at the plasma membrane in activated NK cells and that this is required for initiation of downstream signaling and multiple NK-cell effector functions in vitro and in vivo. Surprisingly, we found that 2 types of proximal signaling complexes involving SLP-76 were formed. In addition to the canonical membrane complex formed between SLP-76 and linker for activation of T cells (LAT) family members, a novel LAT family-"],"journal":["Blood"],"pubmed_title":["Murine natural killer immunoreceptors use distinct proximal signaling complexes to direct cell function."],"pmcid":["PMC3630829"],"funding_grant_id":["L40 AI084669","R01 HL107589","R21 AI073409","K08HL086503","T32AR007442","R21AI073409","R01HL111501","T32 AR007442","K08 HL086503","R01AI067946","R01 AI067946","R01 HL111501","R01 HL089745","R01HL089745","K08 CA166184","R01HL107589"],"pubmed_authors":["May RM","Okumura M","Philip NH","Yang E","Zhang W","Kambayashi T","Rak G","Bassiri H","Orange JS","Mace EM","Hsu CJ","Baumgart T","Nichols KE"],"additional_accession":[]},"is_claimable":false,"name":"Murine natural killer immunoreceptors use distinct proximal signaling complexes to direct cell function.","description":"Signaling pathways leading to natural killer (NK)-cell effector function are complex and incompletely understood. Here, we investigated the proximal signaling pathways downstream of the immunotyrosine-based activation motif (ITAM) bearing activating receptors. We found that the adaptor molecule SH2 domain-containing leukocyte protein of 76 kD (SLP-76) is recruited to microclusters at the plasma membrane in activated NK cells and that this is required for initiation of downstream signaling and multiple NK-cell effector functions in vitro and in vivo. Surprisingly, we found that 2 types of proximal signaling complexes involving SLP-76 were formed. In addition to the canonical membrane complex formed between SLP-76 and linker for activation of T cells (LAT) family members, a novel LAT family-","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Apr","modification":"2025-04-25T22:08:43.483Z","creation":"2019-03-27T01:07:40Z"},"accession":"S-EPMC3630829","cross_references":{"pubmed":["23407547"],"doi":["10.1182/blood-2012-12-474361"]}}