{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(4)"],"submitter":["Schulte BM"],"pubmed_abstract":["Coxsackie B viruses (CVBs) and echoviruses (EVs) form the Human Enterovirus-B (HEV-B) species within the family Picornaviridae. HEV-B infections are widespread and generally cause mild disease; however, severe infections occur and HEV-B are associated with various chronic diseases such as cardiomyopathy and type 1 diabetes. Dendritic cells (DCs) are the professional antigen-presenting cells of our immune system and initiate and control immune responses to invading pathogens, yet also maintain tolerance to self-antigens. We previously reported that EVs, but not CVBs, can productively infect in vitro generated monocyte-derived DCs. The interactions between HEV-B and human myeloid DCs (mDCs) freshly isolated from blood, however, remain unknown. Here, we studied the susceptibility and response"],"journal":["PloS one"],"pagination":["e62502"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3634769"],"repository":["biostudies-literature"],"pubmed_title":["Differential susceptibility and response of primary human myeloid BDCA1(+) dendritic cells to infection with different Enteroviruses."],"pmcid":["PMC3634769"],"pubmed_authors":["Galama JM","van Kuppeveld FJ","Prosser AC","Kers-Rebel ED","Adema GJ","Schulte BM"],"additional_accession":[]},"is_claimable":false,"name":"Differential susceptibility and response of primary human myeloid BDCA1(+) dendritic cells to infection with different Enteroviruses.","description":"Coxsackie B viruses (CVBs) and echoviruses (EVs) form the Human Enterovirus-B (HEV-B) species within the family Picornaviridae. HEV-B infections are widespread and generally cause mild disease; however, severe infections occur and HEV-B are associated with various chronic diseases such as cardiomyopathy and type 1 diabetes. Dendritic cells (DCs) are the professional antigen-presenting cells of our immune system and initiate and control immune responses to invading pathogens, yet also maintain tolerance to self-antigens. We previously reported that EVs, but not CVBs, can productively infect in vitro generated monocyte-derived DCs. The interactions between HEV-B and human myeloid DCs (mDCs) freshly isolated from blood, however, remain unknown. Here, we studied the susceptibility and response","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013","modification":"2025-04-19T09:09:29.199Z","creation":"2019-03-26T23:14:14Z"},"accession":"S-EPMC3634769","cross_references":{"pubmed":["23638101"],"doi":["10.1371/journal.pone.0062502"]}}