biostudies-literatureUnknown8(4)Schulte BMCoxsackie B viruses (CVBs) and echoviruses (EVs) form the Human Enterovirus-B (HEV-B) species within the family Picornaviridae. HEV-B infections are widespread and generally cause mild disease; however, severe infections occur and HEV-B are associated with various chronic diseases such as cardiomyopathy and type 1 diabetes. Dendritic cells (DCs) are the professional antigen-presenting cells of our immune system and initiate and control immune responses to invading pathogens, yet also maintain tolerance to self-antigens. We previously reported that EVs, but not CVBs, can productively infect in vitro generated monocyte-derived DCs. The interactions between HEV-B and human myeloid DCs (mDCs) freshly isolated from blood, however, remain unknown. Here, we studied the susceptibility and responsePloS onee62502https://www.ebi.ac.uk/biostudies/studies/S-EPMC3634769biostudies-literatureDifferential susceptibility and response of primary human myeloid BDCA1(+) dendritic cells to infection with different Enteroviruses.PMC3634769Galama JMvan Kuppeveld FJProsser ACKers-Rebel EDAdema GJSchulte BMfalseDifferential susceptibility and response of primary human myeloid BDCA1(+) dendritic cells to infection with different Enteroviruses.Coxsackie B viruses (CVBs) and echoviruses (EVs) form the Human Enterovirus-B (HEV-B) species within the family Picornaviridae. HEV-B infections are widespread and generally cause mild disease; however, severe infections occur and HEV-B are associated with various chronic diseases such as cardiomyopathy and type 1 diabetes. Dendritic cells (DCs) are the professional antigen-presenting cells of our immune system and initiate and control immune responses to invading pathogens, yet also maintain tolerance to self-antigens. We previously reported that EVs, but not CVBs, can productively infect in vitro generated monocyte-derived DCs. The interactions between HEV-B and human myeloid DCs (mDCs) freshly isolated from blood, however, remain unknown. Here, we studied the susceptibility and response2013-01-01T00:00:00Z20132025-04-19T09:09:29.199Z2019-03-26T23:14:14ZS-EPMC36347692363810110.1371/journal.pone.0062502