biostudies-literatureUnknown8(4)Gong Y<h4>Objective</h4>To investigate the relationship between sex hormones and the risk of vascular disease in elderly men and to evaluate the advantages and disadvantages of testosterone replacement.<h4>Methods</h4>A total of 337 men, aged 60 to 91 years, were enrolled in this single-center, cross-sectional study, and their sex hormone levels were assessed. Linear and logistic regression analyses were utilized to compare the sex hormone levels between patients with and without vascular disease. The nonparametric K-sample test was used for inter-group comparisons.<h4>Results</h4>Aging and abnormal metabolism were both significantly associated with an increased risk of vascular diseases and changes in sex hormone levels. Primary linear and logistic regression analyses showed no significant diffPloS onee61598https://www.ebi.ac.uk/biostudies/studies/S-EPMC3634802biostudies-literatureElevated t/e2 ratio is associated with an increased risk of cerebrovascular disease in elderly men.PMC3634802Li CShao YSun BLu YTian HXiao HJin MBai JGong YCheng XfalseElevated t/e2 ratio is associated with an increased risk of cerebrovascular disease in elderly men.<h4>Objective</h4>To investigate the relationship between sex hormones and the risk of vascular disease in elderly men and to evaluate the advantages and disadvantages of testosterone replacement.<h4>Methods</h4>A total of 337 men, aged 60 to 91 years, were enrolled in this single-center, cross-sectional study, and their sex hormone levels were assessed. Linear and logistic regression analyses were utilized to compare the sex hormone levels between patients with and without vascular disease. The nonparametric K-sample test was used for inter-group comparisons.<h4>Results</h4>Aging and abnormal metabolism were both significantly associated with an increased risk of vascular diseases and changes in sex hormone levels. Primary linear and logistic regression analyses showed no significant diff2013-01-01T00:00:00Z20132025-04-19T09:09:57.679Z2019-03-26T23:14:15ZS-EPMC36348022363786410.1371/journal.pone.0061598