{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ding Q"],"funding":["National Heart, Lung, and Blood Institute of the National Institute of Health","NHLBI NIH HHS"],"pagination":["614-24"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3634890"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["109(4)"],"pubmed_abstract":["Protein C is a vitamin K-dependent serine protease zymogen in plasma which upon activation to activated protein C (APC) by thrombin down-regulates the clotting cascade by limited proteolysis of the procoagulant cofactors Va and VIIIa. In addition to its anticoagulant activity, APC also exhibits potent cytoprotective and anti-inflammatory activities. While the anticoagulant activity of APC is enhanced by the cofactor function of protein S on membrane phospholipids, the cytoprotective intracellular signalling activity of APC requires complex formation with endothelial protein C receptor (EPCR) expressed on the vascular endothelium. Two natural variants of APC [Arg-147 to Trp substitution (R147W) and Lys-150 deletion (K150del)] have been identified in the Chinese population as hotspot mutants"],"journal":["Thrombosis and haemostasis"],"pubmed_title":["Expression and functional characterisation of natural R147W and K150del variants of protein C in the Chinese population."],"pmcid":["PMC3634890"],"funding_grant_id":["R01 HL101917","R01 HL062565","(HL 101917 and HL 62565 to ARR)"],"pubmed_authors":["Yang L","Hassanian SM","Ding Q","Rezaie AR"],"additional_accession":[]},"is_claimable":false,"name":"Expression and functional characterisation of natural R147W and K150del variants of protein C in the Chinese population.","description":"Protein C is a vitamin K-dependent serine protease zymogen in plasma which upon activation to activated protein C (APC) by thrombin down-regulates the clotting cascade by limited proteolysis of the procoagulant cofactors Va and VIIIa. In addition to its anticoagulant activity, APC also exhibits potent cytoprotective and anti-inflammatory activities. While the anticoagulant activity of APC is enhanced by the cofactor function of protein S on membrane phospholipids, the cytoprotective intracellular signalling activity of APC requires complex formation with endothelial protein C receptor (EPCR) expressed on the vascular endothelium. Two natural variants of APC [Arg-147 to Trp substitution (R147W) and Lys-150 deletion (K150del)] have been identified in the Chinese population as hotspot mutants","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Apr","modification":"2025-04-19T09:06:16.92Z","creation":"2019-03-27T01:07:49Z"},"accession":"S-EPMC3634890","cross_references":{"pubmed":["23389250"],"doi":["10.1160/TH12-10-0760","10.1160/th12-10-0760"]}}