biostudies-literatureDing QNational Heart, Lung, and Blood Institute of the National Institute of HealthNHLBI NIH HHS614-24https://www.ebi.ac.uk/biostudies/studies/S-EPMC3634890biostudies-literatureUnknown109(4)Protein C is a vitamin K-dependent serine protease zymogen in plasma which upon activation to activated protein C (APC) by thrombin down-regulates the clotting cascade by limited proteolysis of the procoagulant cofactors Va and VIIIa. In addition to its anticoagulant activity, APC also exhibits potent cytoprotective and anti-inflammatory activities. While the anticoagulant activity of APC is enhanced by the cofactor function of protein S on membrane phospholipids, the cytoprotective intracellular signalling activity of APC requires complex formation with endothelial protein C receptor (EPCR) expressed on the vascular endothelium. Two natural variants of APC [Arg-147 to Trp substitution (R147W) and Lys-150 deletion (K150del)] have been identified in the Chinese population as hotspot mutantsThrombosis and haemostasisExpression and functional characterisation of natural R147W and K150del variants of protein C in the Chinese population.PMC3634890R01 HL101917R01 HL062565(HL 101917 and HL 62565 to ARR)Yang LHassanian SMDing QRezaie ARfalseExpression and functional characterisation of natural R147W and K150del variants of protein C in the Chinese population.Protein C is a vitamin K-dependent serine protease zymogen in plasma which upon activation to activated protein C (APC) by thrombin down-regulates the clotting cascade by limited proteolysis of the procoagulant cofactors Va and VIIIa. In addition to its anticoagulant activity, APC also exhibits potent cytoprotective and anti-inflammatory activities. While the anticoagulant activity of APC is enhanced by the cofactor function of protein S on membrane phospholipids, the cytoprotective intracellular signalling activity of APC requires complex formation with endothelial protein C receptor (EPCR) expressed on the vascular endothelium. Two natural variants of APC [Arg-147 to Trp substitution (R147W) and Lys-150 deletion (K150del)] have been identified in the Chinese population as hotspot mutants2013-01-01T00:00:00Z2013 Apr2025-04-19T09:06:16.92Z2019-03-27T01:07:49ZS-EPMC36348902338925010.1160/TH12-10-076010.1160/th12-10-0760