biostudies-literatureSaxena RBritish Heart FoundationNIDDK NIH HHSMedical Research CouncilNational Institute for Health Research (NIHR)Wellcome Trust1746-55https://www.ebi.ac.uk/biostudies/studies/S-EPMC3636649biostudies-literatureUnknown62(5)We performed a genome-wide association study (GWAS) and a multistage meta-analysis of type 2 diabetes (T2D) in Punjabi Sikhs from India. Our discovery GWAS in 1,616 individuals (842 case subjects) was followed by in silico replication of the top 513 independent single nucleotide polymorphisms (SNPs) (P < 10⁻³) in Punjabi Sikhs (n = 2,819; 801 case subjects). We further replicated 66 SNPs (P < 10⁻⁴) through genotyping in a Punjabi Sikh sample (n = 2,894; 1,711 case subjects). On combined meta-analysis in Sikh populations (n = 7,329; 3,354 case subjects), we identified a novel locus in association with T2D at 13q12 represented by a directly genotyped intronic SNP (rs9552911, P = 1.82 × 10⁻⁸) in the SGCG gene. Next, we undertook in silico replication (stage 2b) of the top 513 signals (P < 10⁻DiabetesGenome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India.PMC3636649R01-DK-082766NF-SI-0611-10219G0801056B098017MR/L003120/1NF-SI-0512-10140MC_U127592696NF-SI-0512-10165MC_PC_U127592696R01 DK082766RG/08/014/24067090532Burtt NPLieverse ANarisu NWichmann HETakayanagi RCrawford GGroves CJMuTHERLauritzen TOng RTZondervan KTBarnett AHKnowles DYin Wong TWalker MGroop LRalhan SGaravito MLCho YMOhnaka KCho YSYoung RHu CKlopp NPalmer CNBuil APankow JSZeggini EFranklin CSChidambaram MThorsteinsdottir UTuomi TCollins FSAltshuler DQi LJackson AUHo WKDaly MJMontgomery SBLiu JJSaxena RFox CSKadowaki TChuang LMNg DPWatanabe RMPotter SKelly MAElliott ALRasheed ARoden MStein LDBonnycastle LLvan Dam RMBataille VKuusisto JRayner NWBjonnes ABoehnke MLiju SMa RCGreen TWijmenga CShrader PChang TJHerder CMohlke KLTravers MEO'Rahilly SGrallert HDupuis JThorleifsson GHirose HKatulanda PWilson JFBraun TRadha VPetersen AKProkopenko IBoehm BOTakeuchi FGriffin SAulchenko YSMarre MGieger CHu FBNakamura JMaeda SChen CHLi Mvan Duijn CMMin JLGanser MDimas ASLi YMcCarroll SAVSegre ABeen LFGuiducci CSijbrands EBell JTMeduri ERathmann WCai QDoney ASGrundberg EHunter DJIllig TPark KSIsomaa BMorris ADDanesh JWitteman JMcCulloch LJHedman AKJin Go MMidthjell Kvan Haeften TWJia WNica ACYee So WPerry JRRocheleau GDermitzakis ETMorris APStringham HMYamauchi TKooner JSMehra NKHitman GAPedersen OOwen KRNavarro PBumpstead SSekowska Mvan Hoek MChang YCPayne FHansen TSmall KSCauchi SThorand BSaleheen DSeielstad MTichet JBergman RNFroguel PBlagieva RHadjadj SMcCarthy MIAinali CIkegami HFlorez JCSigurdsson GRaychaudhuri STai ESZhang RWelch RPTay WTLee NRUitterlinden AParts LArdlie KFrayling TMKao WHDurbin RIngle CSurdulescu GBennett AJZheng WMatthews DSingh JRGlass DTsai FJHattersley ATLaakso MVoight BFDina CTsaprouni LAmin NSparso TMeigs JBRees SDWalters GBWu JYLowe CEAGENDeloukas PFerreira TCho NHTanaka YCornelis MKong AHofman ANisbet JBostrom KBHara KWareham NJCharpentier GSampson MJHassanali NElliott KSFrossard PRobertson NRTobe KPeng-Keat Ng DLee JYSwift AJKim SYokota MScott LJKamboh MIWeedon MNNestle FOGrarup NChang LCMeglio PdLyssenko VLu WStefansson KWang CBoerwinkle EAbecasis GRWu GLindgren CMAung THveem KKeildson SSun QGloyn ALSpector TDMohan VMeitinger TTeo YYWu YYamamoto KBarroso IBravenboer BStrassburger KErdos MRNakashima ETsoka SWong TYGyllensten Uvan Vliet-Ostaptchouk JVMaegawa HKrestyaninova MCouper DJHan BGGao YKraft PTuomilehto JWilk AAdair LSAhmadi KRRader DJChines PSPlatou CWiller CJMorken MALong JHuth CSteinthorsdottir VBarrett Avan Herpt TBalkau BHide WAYang TPKim YJKato NPramstaller PPDIAGRAMBenediktsson RSoranzo NKim HLJohnson PRRudan IJen-Mai Lee JProenca CChan JCBao YShu XOBasit AMulvihill JJSim XLangenberg CSladek RShields BMCampbell HChambers JCHofmann OMKwak SHWander GSChen YTJorgensen TSanghera DKShin SYNilsson PfalseGenome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India.We performed a genome-wide association study (GWAS) and a multistage meta-analysis of type 2 diabetes (T2D) in Punjabi Sikhs from India. Our discovery GWAS in 1,616 individuals (842 case subjects) was followed by in silico replication of the top 513 independent single nucleotide polymorphisms (SNPs) (P < 10⁻³) in Punjabi Sikhs (n = 2,819; 801 case subjects). We further replicated 66 SNPs (P < 10⁻⁴) through genotyping in a Punjabi Sikh sample (n = 2,894; 1,711 case subjects). On combined meta-analysis in Sikh populations (n = 7,329; 3,354 case subjects), we identified a novel locus in association with T2D at 13q12 represented by a directly genotyped intronic SNP (rs9552911, P = 1.82 × 10⁻⁸) in the SGCG gene. Next, we undertook in silico replication (stage 2b) of the top 513 signals (P < 10⁻2013-01-01T00:00:00Z2013 May2026-05-05T10:35:54.185Z2026-04-07T21:36:48.678ZS-EPMC36366492330027810.2337/db12-1077