{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Feitosa MF"],"funding":["NIDDK NIH HHS","NHLBI NIH HHS"],"pagination":["175-80"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3640729"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["228(1)"],"pubmed_abstract":["<h4>Objectives</h4>Nonalcoholic fatty liver disease (NAFLD) ranges from simple steatosis to hepatic inflammation to cirrhosis. We sought to identify common genetic variants contributing to NAFLD, using CT measured fatty liver (FL), and alanine aminotransferase levels (ALT), as a biochemical marker of hepatic inflammation.<h4>Methods</h4>We employed a correlated meta-analysis (CMA) to test whether combining FL and ALT genomewide association (GWA) results, using ∼2.5 million imputed SNPs, could enhance ability to detect variants influencing both traits.<h4>Results</h4>Variants of the ERLIN1-CHUK-CWF19L1 gene cluster were associated with concomitant variation of FL and ALT. Nine variants (rs2862954, rs1408579, rs10883451, rs11597086, rs11591741, rs17729876, rs17668255, rs17668357, rs12784396)"],"journal":["Atherosclerosis"],"pubmed_title":["The ERLIN1-CHUK-CWF19L1 gene cluster influences liver fat deposition and hepatic inflammation in the NHLBI Family Heart Study."],"pmcid":["PMC3640729"],"funding_grant_id":["R01-DK-075681","R01 HL087700","R01 DK075681","R01 DK089256","R01-HL-087700","R01-DK-8925601","R01-HL-088215","R01 HL088215"],"pubmed_authors":["Carr JJ","Borecki IB","Province MA","Feitosa MF","Wojczynski MK","Zhang Q","North KE"],"additional_accession":[]},"is_claimable":false,"name":"The ERLIN1-CHUK-CWF19L1 gene cluster influences liver fat deposition and hepatic inflammation in the NHLBI Family Heart Study.","description":"<h4>Objectives</h4>Nonalcoholic fatty liver disease (NAFLD) ranges from simple steatosis to hepatic inflammation to cirrhosis. We sought to identify common genetic variants contributing to NAFLD, using CT measured fatty liver (FL), and alanine aminotransferase levels (ALT), as a biochemical marker of hepatic inflammation.<h4>Methods</h4>We employed a correlated meta-analysis (CMA) to test whether combining FL and ALT genomewide association (GWA) results, using ∼2.5 million imputed SNPs, could enhance ability to detect variants influencing both traits.<h4>Results</h4>Variants of the ERLIN1-CHUK-CWF19L1 gene cluster were associated with concomitant variation of FL and ALT. Nine variants (rs2862954, rs1408579, rs10883451, rs11597086, rs11591741, rs17729876, rs17668255, rs17668357, rs12784396)","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 May","modification":"2026-05-02T08:24:08.99Z","creation":"2019-03-26T23:06:36Z"},"accession":"S-EPMC3640729","cross_references":{"pubmed":["23477746"],"doi":["10.1016/j.atherosclerosis.2013.01.038"]}}