biostudies-literatureNavarro PNLM NIH HHSDepartment of Defense2604-15https://www.ebi.ac.uk/biostudies/studies/S-EPMC3645290biostudies-literatureUnknown318(20)Neurokinin 1 (NK1) encodes full-length (NK1-FL) and truncated (NK1-Tr) receptors, with distinct 3' UTR. NK1-Tr exerts oncogenic functions and is increased in breast cancer (BC). Enhanced transcription of NK1 resulted in higher level of NK1-Tr. The 3' UTR of these two transcripts are distinct with NK1-Tr terminating at a premature stop codon. NK1-Tr mRNA gained an advantage over NK1-FL with regards to translation. This is due to the ability of miR519B to interact with sequences within the 3' UTR of NK1-FL, but not NK1-Tr since the corresponding region is omitted. MiR519b suppressed the translation of NK1-FL in T47D and MDA-MB-231 resulting in increased NK1-Tr protein. Cytokines can induce the transcription of NK1. However, our studies indicated that translation appeared to be independent ofExperimental cell researchAn indirect role for oncomir-519b in the expression of truncated neurokinin-1 in breast cancer cells.PMC3645290#W81XWH-10-1-0413T15 LM007092Murthy RGRameshwar PShah SGreco SJPark JMPatel SARamkissoon SHNavarro PfalseAn indirect role for oncomir-519b in the expression of truncated neurokinin-1 in breast cancer cells.Neurokinin 1 (NK1) encodes full-length (NK1-FL) and truncated (NK1-Tr) receptors, with distinct 3' UTR. NK1-Tr exerts oncogenic functions and is increased in breast cancer (BC). Enhanced transcription of NK1 resulted in higher level of NK1-Tr. The 3' UTR of these two transcripts are distinct with NK1-Tr terminating at a premature stop codon. NK1-Tr mRNA gained an advantage over NK1-FL with regards to translation. This is due to the ability of miR519B to interact with sequences within the 3' UTR of NK1-FL, but not NK1-Tr since the corresponding region is omitted. MiR519b suppressed the translation of NK1-FL in T47D and MDA-MB-231 resulting in increased NK1-Tr protein. Cytokines can induce the transcription of NK1. However, our studies indicated that translation appeared to be independent of2012-01-01T00:00:00Z2012 Dec2026-04-16T21:23:59.928Z2019-03-27T01:09:34ZS-EPMC36452902298197910.1016/j.yexcr.2012.09.002