{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(4)"],"submitter":["Pala D"],"pubmed_abstract":["Melatonin exerts many of its actions through the activation of two G protein-coupled receptors (GPCRs), named MT1 and MT2. So far, a number of different MT1 and MT2 receptor homology models, built either from the prototypic structure of rhodopsin or from recently solved X-ray structures of druggable GPCRs, have been proposed. These receptor models differ in the binding modes hypothesized for melatonin and melatonergic ligands, with distinct patterns of ligand-receptor interactions and putative bioactive conformations of ligands. The receptor models will be described, and they will be discussed in light of the available information from mutagenesis experiments and ligand-based pharmacophore models. The ability of these ligand-receptor complexes to rationalize structure-activity relationships of known series of melatonergic compounds will be commented upon."],"journal":["International journal of molecular sciences"],"pagination":["8093-121"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3645733"],"repository":["biostudies-literature"],"pubmed_title":["Homology models of melatonin receptors: challenges and recent advances."],"pmcid":["PMC3645733"],"pubmed_authors":["Rivara S","Lodola A","Spadoni G","Bedini A","Pala D"],"additional_accession":[]},"is_claimable":false,"name":"Homology models of melatonin receptors: challenges and recent advances.","description":"Melatonin exerts many of its actions through the activation of two G protein-coupled receptors (GPCRs), named MT1 and MT2. So far, a number of different MT1 and MT2 receptor homology models, built either from the prototypic structure of rhodopsin or from recently solved X-ray structures of druggable GPCRs, have been proposed. These receptor models differ in the binding modes hypothesized for melatonin and melatonergic ligands, with distinct patterns of ligand-receptor interactions and putative bioactive conformations of ligands. The receptor models will be described, and they will be discussed in light of the available information from mutagenesis experiments and ligand-based pharmacophore models. The ability of these ligand-receptor complexes to rationalize structure-activity relationships of known series of melatonergic compounds will be commented upon.","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Apr","modification":"2024-11-20T06:19:42.823Z","creation":"2019-03-27T01:09:35Z"},"accession":"S-EPMC3645733","cross_references":{"pubmed":["23584026"],"doi":["10.3390/ijms14048093"]}}