{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["2(2)"],"submitter":["Yuan W"],"pubmed_abstract":["[2+2+2] Cycloadditions can be applied to specifically build up derivatives of benzene and cyclohexadiene and, therefore, have attracted much attention. Herein, we present an intramolecular [2+2+2] cycloaddition of triynes catalyzed by the first-generation Grubbs ruthenium complex (Ru gen-1), which can efficiently afford benzene derivatives in good yields under mild conditions. Moreover, we also report on a novel tandem cross-metathesis transformation of intramolecular enediynes also catalyzed by Ru gen-1, which has not been observed previously in related reports. On the basis of deuterium labeling experiments, a possible reaction mechanism is presented."],"journal":["ChemistryOpen"],"pagination":["63-8"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3646433"],"repository":["biostudies-literature"],"pubmed_title":["Ruthenium-catalyzed intramolecular [2+2+2] cycloaddition and tandem cross-metathesis of triynes and enediynes."],"pmcid":["PMC3646433"],"pubmed_authors":["Shi M","Yuan W","Wei Y"],"additional_accession":[]},"is_claimable":false,"name":"Ruthenium-catalyzed intramolecular [2+2+2] cycloaddition and tandem cross-metathesis of triynes and enediynes.","description":"[2+2+2] Cycloadditions can be applied to specifically build up derivatives of benzene and cyclohexadiene and, therefore, have attracted much attention. Herein, we present an intramolecular [2+2+2] cycloaddition of triynes catalyzed by the first-generation Grubbs ruthenium complex (Ru gen-1), which can efficiently afford benzene derivatives in good yields under mild conditions. Moreover, we also report on a novel tandem cross-metathesis transformation of intramolecular enediynes also catalyzed by Ru gen-1, which has not been observed previously in related reports. On the basis of deuterium labeling experiments, a possible reaction mechanism is presented.","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Apr","modification":"2025-04-19T17:20:21.739Z","creation":"2019-03-27T01:09:37Z"},"accession":"S-EPMC3646433","cross_references":{"pubmed":["24551536"],"doi":["10.1002/open.201300002"]}}