{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sakuishi K"],"funding":["NIAID NIH HHS"],"pagination":["e23849"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3654601"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2(4)"],"pubmed_abstract":["T-cell immunoglobulin mucin 3 (TIM3) is an inhibitory molecule that has emerged as a key regulator of dysfunctional or exhausted CD8<sup>+</sup> T cells arising in chronic diseases such as cancer. In addition to exhausted CD8<sup>+</sup> T cells, highly suppressive regulatory T cells (Tregs) represent a significant barrier against the induction of antitumor immunity. We have found that the majority of intratumoral FOXP3<sup>+</sup> Tregs express TIM3. TIM3<sup>+</sup> Tregs co-express PD-1, are highly suppressive and comprise a specialized subset of tissue Tregs that are rarely observed in the peripheral tissues or blood of tumor-bearing mice. The co-blockade of the TIM3 and PD-1 signaling pathways in vivo results in the downregulation of molecules associated with TIM3<sup>+</sup> Treg sup"],"journal":["Oncoimmunology"],"pubmed_title":["TIM3<sup>+</sup>FOXP3<sup>+</sup> regulatory T cells are tissue-specific promoters of T-cell dysfunction in cancer."],"pmcid":["PMC3654601"],"funding_grant_id":["P01 AI073748"],"pubmed_authors":["Sullivan JM","Anderson AC","Teng MW","Ngiow SF","Sakuishi K","Kuchroo VK","Smyth MJ"],"additional_accession":[]},"is_claimable":false,"name":"TIM3<sup>+</sup>FOXP3<sup>+</sup> regulatory T cells are tissue-specific promoters of T-cell dysfunction in cancer.","description":"T-cell immunoglobulin mucin 3 (TIM3) is an inhibitory molecule that has emerged as a key regulator of dysfunctional or exhausted CD8<sup>+</sup> T cells arising in chronic diseases such as cancer. In addition to exhausted CD8<sup>+</sup> T cells, highly suppressive regulatory T cells (Tregs) represent a significant barrier against the induction of antitumor immunity. We have found that the majority of intratumoral FOXP3<sup>+</sup> Tregs express TIM3. TIM3<sup>+</sup> Tregs co-express PD-1, are highly suppressive and comprise a specialized subset of tissue Tregs that are rarely observed in the peripheral tissues or blood of tumor-bearing mice. The co-blockade of the TIM3 and PD-1 signaling pathways in vivo results in the downregulation of molecules associated with TIM3<sup>+</sup> Treg sup","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Apr","modification":"2026-05-05T05:36:34.124Z","creation":"2026-04-07T21:29:36.747Z"},"accession":"S-EPMC3654601","cross_references":{"pubmed":["23734331"],"doi":["10.4161/onci.23849"]}}