{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["101(9)"],"submitter":["Bera TK"],"pubmed_abstract":["We identified a gene (NGEP) that is expressed only in prostate cancer and normal prostate. The two NGEP transcripts are 0.9 kb and 3.5 kb in size and are generated by a differential splicing event. The short variant (NGEP-S) is derived from four exons and encodes a 20-kDa intracellular protein. The long form (NGEP-L) is derived from 18 exons and encodes a 95-kDa protein that is predicted to contain seven-membrane-spanning regions. In situ hybridization shows that NGEP mRNA is localized in epithelial cells of normal prostate and prostate cancers. Immunocytochemical analysis of cells transfected with NGEP cDNAs containing a Myc epitope tag at the carboxyl terminus shows that the protein encoded by the short transcript is localized in the cytoplasm, whereas the protein encoded by the long tra"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pagination":["3059-64"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC365744"],"repository":["biostudies-literature"],"pubmed_title":["NGEP, a gene encoding a membrane protein detected only in prostate cancer and normal prostate."],"pmcid":["PMC365744"],"pubmed_authors":["Wolfgang CD","Lee B","Pastan I","Bera TK","Maeda H","Kumar V","Das S","Beers R","Hahn Y"],"additional_accession":[]},"is_claimable":false,"name":"NGEP, a gene encoding a membrane protein detected only in prostate cancer and normal prostate.","description":"We identified a gene (NGEP) that is expressed only in prostate cancer and normal prostate. The two NGEP transcripts are 0.9 kb and 3.5 kb in size and are generated by a differential splicing event. The short variant (NGEP-S) is derived from four exons and encodes a 20-kDa intracellular protein. The long form (NGEP-L) is derived from 18 exons and encodes a 95-kDa protein that is predicted to contain seven-membrane-spanning regions. In situ hybridization shows that NGEP mRNA is localized in epithelial cells of normal prostate and prostate cancers. Immunocytochemical analysis of cells transfected with NGEP cDNAs containing a Myc epitope tag at the carboxyl terminus shows that the protein encoded by the short transcript is localized in the cytoplasm, whereas the protein encoded by the long tra","dates":{"release":"2004-01-01T00:00:00Z","publication":"2004 Mar","modification":"2025-04-04T09:46:48.358Z","creation":"2019-03-27T00:50:11Z"},"accession":"S-EPMC365744","cross_references":{"pubmed":["14981236"],"doi":["10.1073/pnas.0308746101"]}}