biostudies-literatureTODAY Study GroupNCATS NIH HHSNCRR NIH HHSNIDDK NIH HHS1742-8https://www.ebi.ac.uk/biostudies/studies/S-EPMC3661839biostudies-literatureUnknown36(6)<h4>Objective</h4>The Treatment Options for type 2 Diabetes in Adolescents and Youth (TODAY) trial showed superiority of metformin plus rosiglitazone (M+R) over metformin alone (M), with metformin plus lifestyle (M+L) intermediate in maintaining glycemic control. We report here treatment effects on measures of body composition and their relationships to demographic and metabolic variables including glycemia.<h4>Research design and methods</h4>Measures of adiposity (BMI, waist circumference, abdominal height, percent and absolute fat, and bone mineral content [BMC] and density [BMD]) were analyzed as change from baseline at 6 and 24 months.<h4>Results</h4>Measures of fat accumulation were greatest in subjects treated with M+R and least in M+L. Although fat measures in M+L were less than thoDiabetes careTreatment effects on measures of body composition in the TODAY clinical trial.PMC3661839UL1 TR000130M01 RR001066U01 DK061242UL1-RR-024153UL1-RR-025780UL1-RR-024134UL1-RR-024992M01-RR-00125UL1 TR000439UL1-RR-024139M01-RR-00069UL1-RR-024989UL1-RR-025758U01-DK-61230UL1 RR024139U01-DK-61254UL1 RR024134UL1 RR024992U01-DK-61212M01 RR000036UL1 RR025780UL1 RR024153U01-DK-61239U01 DK061230M01 RR000084U01 DK061254M01-RR-01066M01 RR014467UL1 TR000005U01 DK061239U01 DK061212UL1 TR000448M01-RR-00036UL1 RR024989UL1 RR025758M01-RR-00084U01-DK-61242M01 RR000125M01 RR000069M01 RR000043M01-RR-00043-45Shepherd JCopeland KCPyle LGrey MLipman THWashington GHirst KEl ghormli LTODAY Study GroupKriska AMDelahanty LHiggins JfalseTreatment effects on measures of body composition in the TODAY clinical trial.<h4>Objective</h4>The Treatment Options for type 2 Diabetes in Adolescents and Youth (TODAY) trial showed superiority of metformin plus rosiglitazone (M+R) over metformin alone (M), with metformin plus lifestyle (M+L) intermediate in maintaining glycemic control. We report here treatment effects on measures of body composition and their relationships to demographic and metabolic variables including glycemia.<h4>Research design and methods</h4>Measures of adiposity (BMI, waist circumference, abdominal height, percent and absolute fat, and bone mineral content [BMC] and density [BMD]) were analyzed as change from baseline at 6 and 24 months.<h4>Results</h4>Measures of fat accumulation were greatest in subjects treated with M+R and least in M+L. Although fat measures in M+L were less than tho2013-01-01T00:00:00Z2013 Jun2025-04-22T07:11:01.957Z2019-03-27T01:10:18ZS-EPMC36618392370467310.2337/dc12-2534