{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["288(21)"],"submitter":["Lee GS"],"funding":["Intramural NIH HHS"],"pubmed_abstract":["TTLL5/STAMP (tubulin tyrosine ligase-like family member 5) has multiple activities in cells. TTLL5 is one of 13 TTLLs, has polyglutamylation activity, augments the activity of p160 coactivators (SRC-1 and TIF2) in glucocorticoid receptor-regulated gene induction and repression, and displays steroid-independent growth activity with several cell types. To examine TTLL5/STAMP functions in whole animals, mice were prepared with an internal deletion that eliminated several activities of the Stamp gene. This mutation causes both reduced levels of STAMP mRNA and C-terminal truncation of STAMP protein. Homozygous targeted mutant (Stamp(tm/tm)) mice appear normal except for marked decreases in male fertility associated with defects in progressive sperm motility. Abnormal axonemal structures with lo"],"journal":["The Journal of biological chemistry"],"pagination":["15167-80"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3663537"],"repository":["biostudies-literature"],"pubmed_title":["Disruption of Ttll5/stamp gene (tubulin tyrosine ligase-like protein 5/SRC-1 and TIF2-associated modulatory protein gene) in male mice causes sperm malformation and infertility."],"pmcid":["PMC3663537"],"pubmed_authors":["Armstrong SP","Lee GS","Dougherty EJ","London EC","He Y","Jimenez-Movilla M","Zhang Z","Avella M","Grullon S","Blackford JA","Chen W","Awasthi S","Guo C","Simons SS","Sharlin DS","Dean J"],"additional_accession":[]},"is_claimable":false,"name":"Disruption of Ttll5/stamp gene (tubulin tyrosine ligase-like protein 5/SRC-1 and TIF2-associated modulatory protein gene) in male mice causes sperm malformation and infertility.","description":"TTLL5/STAMP (tubulin tyrosine ligase-like family member 5) has multiple activities in cells. TTLL5 is one of 13 TTLLs, has polyglutamylation activity, augments the activity of p160 coactivators (SRC-1 and TIF2) in glucocorticoid receptor-regulated gene induction and repression, and displays steroid-independent growth activity with several cell types. To examine TTLL5/STAMP functions in whole animals, mice were prepared with an internal deletion that eliminated several activities of the Stamp gene. This mutation causes both reduced levels of STAMP mRNA and C-terminal truncation of STAMP protein. Homozygous targeted mutant (Stamp(tm/tm)) mice appear normal except for marked decreases in male fertility associated with defects in progressive sperm motility. Abnormal axonemal structures with lo","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 May","modification":"2026-04-13T13:54:07.857Z","creation":"2019-03-27T01:10:23Z"},"accession":"S-EPMC3663537","cross_references":{"pubmed":["23558686"],"doi":["10.1074/jbc.M113.453936","10.1074/jbc.m113.453936"]}}