{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["33(3)"],"submitter":["Ghorpade DS"],"pubmed_abstract":["Hedgehog (HH) signaling is a significant regulator of cell fate decisions during embryogenesis, development, and perpetuation of various disease conditions. Testing whether pathogen-specific HH signaling promotes unique innate recognition of intracellular bacteria, we demonstrate that among diverse Gram-positive or Gram-negative microbes, Mycobacterium bovis BCG, a vaccine strain, elicits a robust activation of Sonic HH (SHH) signaling in macrophages. Interestingly, sustained tumor necrosis factor alpha (TNF-α) secretion by macrophages was essential for robust SHH activation, as TNF-α(-/-) macrophages exhibited compromised ability to activate SHH signaling. Neutralization of TNF-α or blockade of TNF-α receptor signaling significantly reduced the infection-induced SHH signaling activation b"],"journal":["Molecular and cellular biology"],"pagination":["543-56"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3666883"],"repository":["biostudies-literature"],"pubmed_title":["Sonic hedgehog-dependent induction of microRNA 31 and microRNA 150 regulates Mycobacterium bovis BCG-driven toll-like receptor 2 signaling."],"pmcid":["PMC3666883"],"pubmed_authors":["Holla S","Balaji KN","Kaveri SV","Bayry J","Ghorpade DS","Patil SA"],"additional_accession":[]},"is_claimable":false,"name":"Sonic hedgehog-dependent induction of microRNA 31 and microRNA 150 regulates Mycobacterium bovis BCG-driven toll-like receptor 2 signaling.","description":"Hedgehog (HH) signaling is a significant regulator of cell fate decisions during embryogenesis, development, and perpetuation of various disease conditions. Testing whether pathogen-specific HH signaling promotes unique innate recognition of intracellular bacteria, we demonstrate that among diverse Gram-positive or Gram-negative microbes, Mycobacterium bovis BCG, a vaccine strain, elicits a robust activation of Sonic HH (SHH) signaling in macrophages. Interestingly, sustained tumor necrosis factor alpha (TNF-α) secretion by macrophages was essential for robust SHH activation, as TNF-α(-/-) macrophages exhibited compromised ability to activate SHH signaling. Neutralization of TNF-α or blockade of TNF-α receptor signaling significantly reduced the infection-induced SHH signaling activation b","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Feb","modification":"2026-05-05T09:10:26.608Z","creation":"2026-04-07T21:36:59.606Z"},"accession":"S-EPMC3666883","cross_references":{"pubmed":["23166298"],"doi":["10.1128/mcb.01108-12","10.1128/MCB.01108-12"]}}