biostudies-literatureRhee CMNIDDK NIH HHS2326-36https://www.ebi.ac.uk/biostudies/studies/S-EPMC3667266biostudies-literatureUnknown98(6)<h4>Context</h4>Studies examining the association between subclinical hypothyroidism and mortality have yielded conflicting results. Emerging data suggest these associations may depend upon underlying congestive heart failure (CHF) and/or race, but this has not been empirically determined.<h4>Objective</h4>Our objective was to examine the association between subclinical hypothyroidism and hypothyroidism overall with mortality according to pre-existing CHF and race.<h4>Design and participants</h4>We examined the associations of subclinical hypothyroidism (TSH higher than assay upper limit of normal; total T4 within reference) and hypothyroidism overall (TSH higher than assay upper limit of normal; total T4 below lower limit of normal or within reference) with all-cause mortality among ThirdThe Journal of clinical endocrinology and metabolismSubclinical hypothyroidism and survival: the effects of heart failure and race.PMC3667266F32 DK093201DK91417DK093201K23 DK079056K24 DK091417DK079056Rhee CMBrunelli SMAlexander EKBhan ICurhan GCfalseSubclinical hypothyroidism and survival: the effects of heart failure and race.<h4>Context</h4>Studies examining the association between subclinical hypothyroidism and mortality have yielded conflicting results. Emerging data suggest these associations may depend upon underlying congestive heart failure (CHF) and/or race, but this has not been empirically determined.<h4>Objective</h4>Our objective was to examine the association between subclinical hypothyroidism and hypothyroidism overall with mortality according to pre-existing CHF and race.<h4>Design and participants</h4>We examined the associations of subclinical hypothyroidism (TSH higher than assay upper limit of normal; total T4 within reference) and hypothyroidism overall (TSH higher than assay upper limit of normal; total T4 below lower limit of normal or within reference) with all-cause mortality among Third2013-01-01T00:00:00Z2013 Jun2025-05-29T19:20:02.42Z2025-05-29T19:20:02.42ZS-EPMC36672662372078810.1210/jc.2013-1039